Post-traumatic stress disorder (PTSD) is a prevalent, debilitating and sometimes deadly
consequence of exposure to severe psychological trauma. Although effective treatments …

The bed nucleus of the stria terminalis (BNST) is a center of integration for limbic information
and valence monitoring. The BNST, sometimes referred to as the extended amygdala, is …

The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

Recent years have seen increased interest in psychopathologies related to trauma
exposure. Specifically, there has been a growing awareness to posttraumatic stress disorder …

Dysregulation of the corticotropin-releasing factor (CRF)–urocortin (UCN) system has been
implicated in stress-related psychopathologies such as depression and anxiety. It has been …

The link between dysregulated serotonergic activity and depression and anxiety disorders is
well established, yet the molecular mechanisms underlying these psychopathologies are not …

Post-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric
condition. However, the biological mechanisms underlying this disease are still largely …

Chronic restraint stress leads to increases in brain derived neurotrophic factor (BDNF)
mRNA and protein in some regions of the brain, eg the basal lateral amygdala (BLA) but …

Background: Dysregulated stress neurocircuits, caused by genetic and/or environmental
changes, underlie the development of many neuropsychiatric disorders. Corticotropin …

The goals of animal research in post-traumatic stress disorder (PTSD) include better
understanding the neurophysiological etiology of PTSD, identifying potential targets for …