Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

Fibroblast growth factor receptors (FGFRs) are aberrantly activated through single-
nucleotide variants, gene fusions and copy number amplifications in 5–10% of all human …

Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that gets inputs from
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …

Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular
processes. Deregulation of FGFR signalling is observed in a subset of many cancers …

Abstract The first joint European Society for Medical Oncology (ESMO), European SocieTy
for Radiotherapy & Oncology (ESTRO) and European Society of Gynaecological Oncology …

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Purpose: Molecular profiling may have prognostic and predictive value, and is increasingly
used in the clinical setting. There are more than a dozen fibroblast growth factor receptor …

Purpose This two-part, first-in-human study was initiated in patients with advanced solid
tumors harboring genetic alterations in fibroblast growth factor receptors (FGFRs) to …

The fibroblast growth factor signaling pathway (FGFR signaling) is an evolutionary
conserved signaling cascade that regulates several basic biologic processes, including …

Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …