The immunology of Plasmodium vivax malaria

LR Antonelli, C Junqueira, JM Vinetz… - Immunological …, 2020 - Wiley Online Library
Plasmodium vivax infection, the predominant cause of malaria in Asia and Latin America,
affects~ 14 million individuals annually, with considerable adverse effects on wellbeing and …

[HTML][HTML] Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review

JC Cutts, PA Agius, Z Lin, R Powell, K Moore, B Draper… - BMC medicine, 2020 - Springer
Background In endemic areas, pregnant women are highly susceptible to Plasmodium
falciparum malaria characterized by the accumulation of parasitized red blood cells (pRBC) …

[HTML][HTML] Designing a VAR2CSA-based vaccine to prevent placental malaria

M Fried, PE Duffy - Vaccine, 2015 - Elsevier
Placental malaria (PM) due to Plasmodium falciparum is a major cause of maternal, fetal
and infant mortality, but the mechanisms of pathogenesis and protective immunity are …

[HTML][HTML] Progress and insights toward an effective placental malaria vaccine

B Gamain, A Chêne, NK Viebig… - Frontiers in …, 2021 - frontiersin.org
In areas where Plasmodium falciparum transmission is endemic, clinical immunity against
malaria is progressively acquired during childhood and adults are usually protected against …

Blood-stage malaria parasite antigens: structure, function, and vaccine potential

ND Salinas, WK Tang, NH Tolia - Journal of molecular biology, 2019 - Elsevier
Plasmodium parasites are the causative agent of malaria, a disease that kills approximately
450,000 individuals annually, with the majority of deaths occurring in children under the age …

Clinical outcomes of submicroscopic infections and correlates of protection of VAR2CSA antibodies in a longitudinal study of pregnant women in Colombia

K Gavina, S Gnidehou, E Arango… - Infection and …, 2018 - Am Soc Microbiol
Malaria in pregnancy can cause serious adverse outcomes for the mother and the fetus.
However, little is known about the effects of submicroscopic infections (SMIs) in pregnancy …

Pre-clinical and clinical development of the first placental malaria vaccine

C Pehrson, A Salanti, TG Theander… - Expert Review of …, 2017 - Taylor & Francis
Introduction: Malaria during pregnancy is a massive health problem in endemic areas.
Placental malaria infections caused by Plasmodium falciparum are responsible for up to one …

Progress and new horizons toward a VAR2CSA-based placental malaria vaccine

JYA Doritchamou, J Suurbaar… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Several malaria vaccines are under various phases of development with some
promising results. In placental malaria (PM) a deliberately anti-disease approach is …

Cross-Species Immune Recognition Between Plasmodium vivax Duffy Binding Protein Antibodies and the Plasmodium falciparum Surface Antigen VAR2CSA

S Gnidehou, CJ Mitran, E Arango… - The Journal of …, 2019 - academic.oup.com
Abstract Background In pregnancy, Plasmodium falciparum parasites express the surface
antigen VAR2CSA, which mediates adherence of red blood cells to chondroitin sulfate A …

IgG responses to the Plasmodium falciparum antigen VAR2CSA in Colombia are restricted to pregnancy and are not induced by exposure to Plasmodium vivax

M Lopez-Perez, MD Larsen, R Bayarri-Olmos… - Infection and …, 2018 - Am Soc Microbiol
Clinical immunity to malaria is associated with the acquisition of IgG specific for members of
the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally …