The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and
programmed cell death protein 1 (PD1) as negative regulators of antitumour immunity led to …

The tumor necrosis factor superfamily (TNFSF) and their receptors (TNFRSF) are important
regulators of the immune system, mediating proliferation, survival, differentiation, and …

Simple Summary The tumoral microenvironment comprises cancer cells and surrounding
components, including immune and endothelial cells, along with the extracellular matrix. As …

Immunotherapy is amongst the most promising new treatment modalities to arise over the
last two decades; antibody drugs are delivering immunotherapy to millions of patients with …

Background Previous studies have demonstrated that PANoptosis is strongly correlated with
cancer immunity and progression. This study aimed to develop a PANoptosis-related …

Simple Summary The discovery of prognostic biomarkers constitutes an important issue
because it allows the tailoring of therapeutic treatments, thus avoiding over-treatment and …

Hypoxia is a common feature of solid tumors that can induce endoplasmic reticulum stress
(ERS). This study aimed to explore the mechanism behind tumor-associated macrophages …

Preclinical murine data indicate that fragment crystallizable (Fc)-dependent depletion of
intratumoral regulatory T cells (Treg) is a major mechanism of action of anti–CTLA-4 …

Despite pre-clinical murine data supporting T regulatory (Treg) cell depletion as a major
mechanism by which anti-CTLA-4 antibodies function in vivo, the two main antibodies tested …

Cancer-related inflammation has recently emerged as an important component of cancer
pathogenesis that is able to promote tumor initiation and progression, and the acquisition of …