[HTML][HTML] Pathophysiology of fibrosis in the vocal fold: current research, future treatment strategies, and obstacles to restoring vocal fold pliability

Y Kumai - International journal of molecular sciences, 2019 - mdpi.com
Communication by voice depends on symmetrical vibrations within the vocal folds (VFs) and
is indispensable for various occupations. VF scarring is one of the main reasons for …

[HTML][HTML] Inflammatory pathways in the pathogenesis of iatrogenic laryngotracheal stenosis: what do we know?

RJ Davis, AT Hillel - Translational Cancer Research, 2020 - ncbi.nlm.nih.gov
Iatrogenic laryngotracheal stenosis (LTS) is pathologic airway narrowing due to scar
formation following endotracheal intubation or tracheostomy. It is a chronic and recurrent …

Pathologic fibroblasts in idiopathic subglottic stenosis amplify local inflammatory signals

RJ Morrison, NG Katsantonis, KM Motz… - … –Head and Neck …, 2019 - journals.sagepub.com
Objective To characterize the phenotype and function of fibroblasts derived from airway scar
in idiopathic subglottic stenosis (iSGS) and to explore scar fibroblast response to interleukin …

Progress in vocal fold regenerative biomaterials: an immunological perspective

PT Coburn, X Li, J Li, Y Kishimoto… - Advanced …, 2022 - Wiley Online Library
Vocal folds are important to daily breathing, speech, and swallowing functions. Irreversible
changes to the vocal fold mucosa, such as scarring and atrophy, require regenerative …

In vitro evaluation of anti‐fibrotic effects of select cytokines for vocal fold scar treatment

H Chen, J Erndt‐Marino… - … Research Part B …, 2019 - Wiley Online Library
Scarring of the vocal fold lamina propria (LP) can cause considerable voice disorders due to
reduced pliability in scar tissue, attributed in part to abnormal extracellular matrix (ECM) …

Dysregulated macrophages are present in bleomycin-induced murine laryngotracheal stenosis

AT Hillel, I Samad, G Ma, D Ding… - … –Head and Neck …, 2015 - journals.sagepub.com
Objective To define the inflammatory cell infiltrate preceding fibrosis in a laryngotracheal
stenosis (LTS) murine model. Study Design Prospective controlled murine study. Setting …

An in vitro assessment of the response of THP‐1 macrophages to varying stiffness of a glycol‐chitosan hydrogel for vocal fold tissue engineering applications

PT Coburn, AC Herbay, M Berrini… - Journal of Biomedical …, 2021 - Wiley Online Library
The physical properties of a biomaterial play an essential role in regulating immune and
reparative activities within the host tissue. This study aimed to evaluate the immunological …

Effects of electronic (e)‐cigarette vapor and cigarette smoke in cultured vocal fold fibroblasts

JD Martinez, M Easwaran, D Ramirez… - The …, 2023 - Wiley Online Library
Objective The public use of electronic‐cigarettes (e‐cigs) is rapidly growing. When heated, e‐
cigs produce a vapor that is inhaled. The vocal folds are among the first tissues exposed to …

[HTML][HTML] In vitro mechanical vibration down-regulates pro-inflammatory and pro-fibrotic signaling in human vocal fold fibroblasts

D Hortobagyi, T Grossmann, M Tschernitz, M Grill… - plos One, 2020 - journals.plos.org
Introduction Voice rest following phonotrauma or phonosurgery has a considerable clinical
impact, but clinical recommendations are inconsistent due to inconclusive data. As biopsies …

Porcine vocal fold lamina propria-derived biomaterials modulate TGF-β1-mediated fibroblast activation in vitro

C Mora-Navarro, A Badileanu… - ACS biomaterials …, 2020 - ACS Publications
The vocal fold lamina propria (VFLP), one of the outermost layers of the vocal fold (VF), is
composed of tissue-specific extracellular matrix (ECM) proteins and is highly susceptible to …