Glycosaminoglycans are natural heteropolysaccharides that are present in every
mammalian tissue. They are composed of repeating disaccharide units that consist of either …

Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …

The expression of proteoglycans (PGs), essential macromolecules of the tumor
microenvironment, is markedly altered during malignant transformation and tumor …

The tumor microenvironment (TME) is influenced by a" disorganized" extracellular matrix
(ECM) that sensitizes cancer cells toward mechanical stress, signaling, and structural …

Proteoglycans control numerous normal and pathological processes, among which are
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …

Increased expression of the proteoglycan, versican is strongly associated with poor outcome
for many different cancers. Depending on the cancer type, versican is expressed by either …

Proteoglycans are a group of molecules that contain at least one glycosaminoglycan chain,
such as a heparan, dermatan, chondroitin, or keratan sulfate, covalently attached to the …

Versican has been reported to participate in carcinogenesis in several malignant tumors.
However, the accurate role of VersicanV1, a predominant isoform of Versican in liver …

The exploitation of T cell-based immunotherapies and immune checkpoint blockade for
cancer treatment has dramatically shifted oncological treatment paradigms and broadened …

Objective—Thoracic aortic aneurysm (TAA), a degenerative disease of the aortic wall, is
accompanied by changes in the structure and composition of the aortic ECM (extracellular …