Epigenetics refers to the heritable changes in gene expression without a change in the DNA
sequence itself. Two of these major changes include aberrant DNA methylation as well as …

The modulation of the activity of DNA methyltransferases (DNMTs) represents a crucial
epigenetic mechanism affecting gene expressions or DNA repair mechanisms in the cells …

Blood circulating cell-free DNA (ccfDNA) is a suggested biosource of valuable clinical
information for cancer, meeting the need for a minimally-invasive advancement in the route …

Bromodomain and Extra‐Terminal (BET) proteins are historically involved in regulating gene
expression and BRD4 was recently found to be involved in DNA damage regulation. Aims of …

To address the problem of resistance to paclitaxel treatment, we have investigated to which
extent is possible to predict Breast Cancer (BC) patient response to this drug. We carried out …

Obesity is a high risk factor for breast cancer. This relationship could be marked by a specific
methylome. The current work was aimed to explore the impact of obesity and menopausal …

Progesterone and its receptor, PR, are essential for uterine leiomyoma (LM, aka, fibroid)
tumorigenesis, but the underlying cellular and molecular mechanisms remain unclear. The …

Purpose: Inhibition of AKT is a key target area for personalized cancer medicine. However,
predictive markers of response to AKT inhibitors are lacking. Correspondingly, the AKT …

Background Breast carcinogenesis is a multistep process involving genetic and epigenetic
changes. Tumor tissues are frequently characterized by gene-specific hypermethylation and …

Identification of lncRNA biomarkers for lung cancer through integrative cross-platform data
analyses - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …