Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Painful diabetic peripheral neuropathy occurs in approximately 25% of patients with
diabetes mellitus who are treated in the office setting and significantly affects quality of life. It …

There is a high prevalence of painful diabetic polyneuropathy (pDPN) with around one-third
of all patients with diabetes suffering from pDPN. pDPN has debilitating consequences, with …

Background Neuropathic pain, which is caused by nerve damage, is increasing in
prevalence worldwide. This may reflect improved diagnosis, or it may be due to increased …

Background Chronic pain is common in adults, and often has a detrimental impact upon
physical ability, well‐being, and quality of life. Previous reviews have shown that certain …

Background Antidepressants are widely used to treat chronic neuropathic pain (pain due to
nerve damage), usually in doses below those at which they exert antidepressant effects. An …

Numerous interventions for neuropathic pain (NeuP) are available, but its treatment remains
unsatisfactory. We systematically summarized evidence from systematic reviews (SRs) of …

Painful diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus,
affecting, by some estimates, up to one quarter of diabetic patients. Since 2010, no fewer …

Chemotherapy may have detrimental effects on either the central or peripheral nervous
system. Central nervous system neurotoxicity resulting from chemotherapy manifests as a …

Diabetic peripheral neuropathy (DPN) is a major complication of diabetes mellitus. Tight
glycaemic management focused on lowering haemoglobin A1C and increasing time in the …