Simple Summary Glioblastoma multiforme (GBM) is one of the most aggressive
malignancies, accounting for 14.5% of all central nervous system tumors and 48.6% of …

Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …

The tumor suppressor and transcription factor p53 plays critical roles in tumor prevention by
orchestrating a wide variety of cellular responses, including damaged cell apoptosis …

Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …

This review explores the interface between circadian timekeeping and the regulation of
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …

Human neural organoids, generated from pluripotent stem cells in vitro, are useful tools to
study human brain development, evolution and disease. However, it is unclear which parts …

Glioblastoma is the most common and most aggressive primary brain tumor. Despite
maximum treatment, patients only have a median survival time of 15 months, because of the …

Purpose To define copy number alterations and gene expression signatures underlying
pediatric high-grade glioma (HGG). Patients and Methods We conducted a high-resolution …

The median survival of glioblastoma patients is∼ 12 months. However, 3–5% of the patients
survives for more than 3 years and are referred to as long-term survivors. The clinical and …

Purpose The prognostic value of genetic alterations characteristic of glioblastoma in patients
treated according to present standards of care is unclear. Patients and Methods Three …