Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of
many cellular proteins. Cellular zinc homeostasis involves the opposing action of two …

Zinc is an essential element and serves as a structural or catalytic component in many
proteins. Two families of transporters are involved in maintaining cellular zinc homeostasis …

During tumor progression, lysosome function is often maladaptively upregulated to match
the high energy demand required for cancer cell hyper-proliferation and invasion. Here, we …

As a nutritionally essential metal ion, zinc (Zn) not only constitutes a structural element for
more than 3000 proteins but also plays important regulatory functions in cellular signal …

Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cancer
cases annually. Here we present a thermodynamic model that quantifies and links the major …

Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn 2+
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …

Transient early endosome (EE)-mitochondria interactions can mediate mitochondrial iron
translocation, but the associated mechanisms are still elusive. We showed that Divalent …

Background Preeclampsia (PE) is a multi-organ syndrome that onsets in the second half of
pregnancy. It is the second leading cause of maternal death globally. The homeostasis of …

Triple-negative breast cancer (TNBC) is usually the most malignant and aggressive
mammary epithelial tumor characterized by the lack of expression for estrogen receptors …