Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets
Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …
key observation is the disruption of cellular homeostasis, often coinciding with disease …
The emerging role of zinc transporters in cellular homeostasis and cancer
E Bafaro, Y Liu, Y Xu, RE Dempski - Signal transduction and targeted …, 2017 - nature.com
Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of
many cellular proteins. Cellular zinc homeostasis involves the opposing action of two …
many cellular proteins. Cellular zinc homeostasis involves the opposing action of two …
[HTML][HTML] Zinc dysregulation in cancers and its potential as a therapeutic target
J Wang, H Zhao, Z Xu, X Cheng - Cancer biology & medicine, 2020 - ncbi.nlm.nih.gov
Zinc is an essential element and serves as a structural or catalytic component in many
proteins. Two families of transporters are involved in maintaining cellular zinc homeostasis …
proteins. Two families of transporters are involved in maintaining cellular zinc homeostasis …
[HTML][HTML] Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma
During tumor progression, lysosome function is often maladaptively upregulated to match
the high energy demand required for cancer cell hyper-proliferation and invasion. Here, we …
the high energy demand required for cancer cell hyper-proliferation and invasion. Here, we …
[HTML][HTML] Zinc transporters and dysregulated channels in cancers
As a nutritionally essential metal ion, zinc (Zn) not only constitutes a structural element for
more than 3000 proteins but also plays important regulatory functions in cellular signal …
more than 3000 proteins but also plays important regulatory functions in cellular signal …
Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants
AR Blanden, X Yu, AJ Blayney, C Demas, JH Ha, Y Liu… - Elife, 2020 - elifesciences.org
Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cancer
cases annually. Here we present a thermodynamic model that quantifies and links the major …
cases annually. Here we present a thermodynamic model that quantifies and links the major …
How cellular Zn2+ signaling drives physiological functions
N Levaot, M Hershfinkel - Cell Calcium, 2018 - Elsevier
Zinc is an essential micronutrient affecting many aspects of human health. Cellular Zn 2+
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …
homeostasis is critical for cell function and survival. Zn 2+, acting as a first or second …
DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth
Transient early endosome (EE)-mitochondria interactions can mediate mitochondrial iron
translocation, but the associated mechanisms are still elusive. We showed that Divalent …
translocation, but the associated mechanisms are still elusive. We showed that Divalent …
Maternal serum zinc level is associated with risk of preeclampsia: a systematic review and meta-analysis
S Jin, C Hu, Y Zheng - Frontiers in Public Health, 2022 - frontiersin.org
Background Preeclampsia (PE) is a multi-organ syndrome that onsets in the second half of
pregnancy. It is the second leading cause of maternal death globally. The homeostasis of …
pregnancy. It is the second leading cause of maternal death globally. The homeostasis of …
Updates on triple-negative breast cancer in type 2 diabetes mellitus patients: from risk factors to diagnosis, biomarkers and therapy
S Matou-Nasri, M Aldawood, F Alanazi, AL Khan - Diagnostics, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is usually the most malignant and aggressive
mammary epithelial tumor characterized by the lack of expression for estrogen receptors …
mammary epithelial tumor characterized by the lack of expression for estrogen receptors …