Controlling the biodistribution and clearance of nanomedicines

H Cabral, J Li, K Miyata, K Kataoka - Nature Reviews Bioengineering, 2024 - nature.com
Nanomedicines improve drug bioavailability, the dose–response relationship, targeting
ability, efficacy and safety compared to conventional freely administered drugs …

Polymeric nanoparticle-based nanovaccines for cancer immunotherapy

Y Zhang, J Chen, L Shi, F Ma - Materials Horizons, 2023 - pubs.rsc.org
Therapeutic cancer vaccines, which are designed to amplify tumor-specific T cell responses,
have been envisioned as one of the most powerful tools for effective cancer immunotherapy …

Multifunctional Au@AgBiS2 Nanoparticles as High‐Efficiency Radiosensitizers to Induce Pyroptosis for Cancer Radioimmunotherapy

L Xiao, B Chen, W Wang, T Tian, H Qian… - Advanced …, 2023 - Wiley Online Library
Radiotherapy (RT), a widely used clinical treatment modality for cancer, uses high‐energy
irradiation for reactive oxygen species (ROS) production and DNA damage. However, its …

Radiation-induced tumor immune microenvironments and potential targets for combination therapy

S Guo, Y Yao, Y Tang, Z Xin, D Wu, C Ni… - … and Targeted Therapy, 2023 - nature.com
As one of the four major means of cancer treatment including surgery, radiotherapy (RT),
chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical …

Immunotherapeutic Hydrogel with Photothermal Induced Immunogenic Cell Death and STING Activation for Post‐Surgical Treatment

M Wang, X Zhang, B Liu, C Liu, C Song… - Advanced Functional …, 2023 - Wiley Online Library
Post‐surgical tumor recurrence remains a major clinical concern for patients with malignant
solid tumors. Herein, an immunotherapeutic hydrogel (SAPBA/ZMC/ICG) is developed by …

A local water molecular-heating strategy for near-infrared long-lifetime imaging-guided photothermal therapy of glioblastoma

D Kang, HS Kim, S Han, Y Lee, YP Kim, DY Lee… - Nature …, 2023 - nature.com
Owing to the strong absorption of water in the near-infrared (NIR) region near 1.0 μm, this
wavelength is considered unsuitable as an imaging and analytical signal in biological …

In Situ Self‐Aggregation of Spirulina Skeleton Fibers Enhances the Efficacy of Anti‐Tumor Thermal Immunotherapy

YD Qi, ZN Zhuang, SM Zeng, Y Tang… - Advanced Functional …, 2024 - Wiley Online Library
The lack of broad‐spectrum tumor antigens, limited immunogenicity of antigens, and
immunosuppressive microenvironment in tumors have impeded the development of cancer …

Albumin-modified gold nanoparticles as novel radiosensitizers for enhancing lung cancer radiotherapy

Y Chen, S Liu, Y Liao, H Yang, Z Chen… - International Journal …, 2023 - Taylor & Francis
Background Considering the strong attenuation of photons and the potential to increase the
deposition of radiation, high-atomic number nanomaterials are often used as …

Radiotherapy-Triggered In Situ Tumor Vaccination Boosts Checkpoint Blockaded Immune Response via Antigen-Capturing Nanoadjuvants

P Xu, J Ma, Y Zhou, Y Gu, X Cheng, Y Wang, Y Wang… - ACS …, 2023 - ACS Publications
In situ vaccination (ISV) formed with the aid of intratumorally injected adjuvants has shed
bright light on enhancing the abscopal therapeutic effects of radiotherapy. However, the …

Hybrid mRNA nano vaccine potentiates antigenic peptide presentation and dendritic cell maturation for effective cancer vaccine therapy and enhances response to …

L Shi, J Yang, Y Nie, Y Huang… - Advanced Healthcare …, 2023 - Wiley Online Library
Cancer vaccines combined with immune checkpoint blockades (ICB) represent great
potential application, yet the insufficient tumor antigen presentation and immature dendritic …