Fucoidan structure and activity in relation to anti-cancer mechanisms

G Van Weelden, M Bobiński, K Okła, WJ Van Weelden… - Marine drugs, 2019 - mdpi.com
Fucoidan is a natural derived compound found in different species of brown algae and in
some animals, that has gained attention for its anticancer properties. However, the exact …

[HTML][HTML] JNK-signaling: A multiplexing hub in programmed cell death

DN Dhanasekaran, EP Reddy - Genes & cancer, 2017 - ncbi.nlm.nih.gov
Jun N-terminal kinases or JNKs have been shown to be involved in a wide array of signaling
events underlying tumorigenesis and tumor progression. Through its interaction with a …

Cadmium induced BEAS-2B cells apoptosis and mitochondria damage via MAPK signaling pathway

X Cao, M Fu, R Bi, X Zheng, B Fu, S Tian, C Liu, Q Li… - Chemosphere, 2021 - Elsevier
Cadmium, a heavy metal pollutant in industrial production, is found in air, water and soil,
which is harmful to human health and can lead to diseases, such as asthma, lung cancer …

A cascade nanoreactor for enhancing sonodynamic therapy on colorectal cancer via synergistic ROS augment and autophagy blockage

Y Zhang, J Zhao, L Zhang, Y Zhao, Y Zhang, L Cheng… - Nano Today, 2023 - Elsevier
The ultrasound-triggered sonodynamic therapy (SDT) with high tissue penetration, high
spatiotemporal selectivity, and non-invasive advantages represents an emerging approach …

Formononetin: a review of its anticancer potentials and mechanisms

KC Tay, LTH Tan, CK Chan, SL Hong… - Frontiers in …, 2019 - frontiersin.org
Cancer, a complex yet common disease, is caused by uncontrolled cell division and
abnormal cell growth due to a variety of gene mutations. Seeking effective treatments for …

Molecular mechanisms for tumour resistance to chemotherapy

ST Pan, ZL Li, ZX He, JX Qiu… - Clinical and Experimental …, 2016 - Wiley Online Library
Chemotherapy is one of the prevailing methods used to treat malignant tumours, but the
outcome and prognosis of tumour patients are not optimistic. Cancer cells gradually …

Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway …

HW Zhang, JJ Hu, RQ Fu, X Liu, YH Zhang, J Li, L Liu… - Scientific reports, 2018 - nature.com
Anticancer activities of flavonoids derived from Tephroseris kirilowii (Turcz.) Holub. were
evaluated in human cancer cells. We isolated and identified, for the first time, eight …

[HTML][HTML] Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury

D Li, W Ren, Z Jiang, L Zhu - Molecular medicine …, 2018 - spandidos-publications.com
Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) is characterized by
uncontrolled progressive lung inflammation. Macrophages serve a key role in the …

Autophagy: a key regulator of homeostasis and disease: an overview of molecular mechanisms and modulators

L Gómez-Virgilio, MC Silva-Lucero, DS Flores-Morelos… - Cells, 2022 - mdpi.com
Autophagy is a highly conserved lysosomal degradation pathway active at basal levels in all
cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it works …

[HTML][HTML] Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt …

Q Zhang, X Wang, S Cao, Y Sun, X He, B Jiang… - Biomedicine & …, 2020 - Elsevier
Berberine, an isoquinoline alkaloid from Coptidis Rhizoma, has been characterized as a
potential anticancer drug due to its good anti-tumor effects. However, the molecular …