Signaling mechanisms regulating endothelial permeability

D Mehta, AB Malik - Physiological reviews, 2006 - journals.physiology.org
The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Cytoskeletal regulation of pulmonary vascular permeability

SM Dudek, JGN Garcia - Journal of applied physiology, 2001 - journals.physiology.org
The endothelial cell (EC) lining of the pulmonary vasculature forms a semipermeable barrier
between the blood and the interstitium of the lung. Disruption of this barrier occurs during …

Crucial role for ecto-5′-nucleotidase (CD73) in vascular leakage during hypoxia

LF Thompson, HK Eltzschig, JC Ibla… - The Journal of …, 2004 - rupress.org
Extracellular adenosine has been widely implicated in adaptive responses to hypoxia. The
generation of extracellular adenosine involves phosphohydrolysis of adenine nucleotide …

Normal endothelium

AR Pries, WM Kuebler - The Vascular Endothelium I, 2006 - Springer
In recent decades, it has become evident that the endothelium is by no means a passive
inner lining of blood vessels. This 'organ'with a large surface (∼ 350 m 2) and a …

The actin cytoskeleton in endothelial cell phenotypes

N Prasain, T Stevens - Microvascular research, 2009 - Elsevier
Endothelium forms a semi-permeable barrier that separates blood from the underlying
tissue. Barrier function is largely determined by cell-cell and cell-matrix adhesions that …

Leukocyte elastase: physiological functions and role in acute lung injury

WL Lee, GP Downey - American journal of respiratory and critical …, 2001 - atsjournals.org
Cytotoxicity and Wound Healing Evidence for the Role of Elastase in ARDS in Humans
Animal Models of Lung Injury and Leukocyte Elastase Studies of Protease Inhibitors and …

A2B adenosine receptor dampens hypoxia-induced vascular leak

T Eckle, M Faigle, A Grenz, S Laucher… - Blood, The Journal …, 2008 - ashpublications.org
Extracellular adenosine has been implicated in adaptation to hypoxia and previous studies
demonstrated a central role in vascular responses. Here, we examined the contribution of …

[图书][B] Pharmaceutical inhalation aerosol technology

AJ Hickey - 2003 - taylorfrancis.com
This thoroughly revised and expanded reference provides authoritative discussions on the
physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors …

Mechanisms regulating endothelial cell barrier function

T Stevens, JGN Garcia, DM Shasby… - … of Physiology-Lung …, 2000 - journals.physiology.org
Endothelium forms a physical barrier that separates blood from tissue. Communication
between blood and tissue occurs through the delivery of molecules and circulating …

Structural and functional characteristics of lung macro-and microvascular endothelial cell phenotypes

J King, T Hamil, J Creighton, S Wu, P Bhat… - Microvascular …, 2004 - Elsevier
Lung macro-and microvascular endothelial cells exhibit unique functional attributes,
including signal transduction and barrier properties. We therefore sought to identify …