Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review

LG de Almeida Chuffa, FRF Seiva… - Journal of Cellular …, 2024 - Wiley Online Library
The endoplasmic reticulum (ER) is crucial for protein quality control, and disruptions in its
function can lead to various diseases. ER stress triggers an adaptive response called the …

Melatonin attenuates oxidative stress-induced apoptosis of bovine ovarian granulosa cells by promoting mitophagy via SIRT1/FoxO1 signaling pathway

G Xu, Y Dong, Z Wang, H Ding, J Wang, J Zhao… - International Journal of …, 2023 - mdpi.com
Oxidative-stress-induced apoptosis of granulosa cells is considered to be a main driver of
follicular atresia. Increasing evidence suggests a protective effect of melatonin against …

A comprehensive and systematic review of the potential neuroprotective effect of quercetin in rat models of spinal cord injury

K Zhu, Z Zheng, Y Zhang, Z Li, A Zhou, C Hu… - Nutritional …, 2024 - Taylor & Francis
Full article: A comprehensive and systematic review of the potential neuroprotective effect of
quercetin in rat models of spinal cord injury Skip to Main Content Taylor and Francis Online …

Alpinumisoflavone activates disruption of calcium homeostasis, mitochondria and autophagosome to suppress development of endometriosis

J Song, J Ham, S Park, SJ Park, HS Kim, G Song… - Antioxidants, 2023 - mdpi.com
Alpinumisoflavone is an isoflavonoid extracted from the Cudrania tricuspidate fruit and
Genista pichisermolliana. It has various physiological functions, such as anti-inflammation …

Fraxetin reduces endometriotic lesions through activation of ER stress, induction of mitochondria-mediated apoptosis, and generation of ROS

J Ham, W Park, J Song, HS Kim, G Song, W Lim… - Phytomedicine, 2024 - Elsevier
Background Fraxetin, a phytochemical obtained from Fraxinus rhynchophylla, is well known
for its anti-inflammatory and anti-fibrotic properties. However, fraxetin regulates the …

Why are aging and stress associated with dementia, cancer, and other diverse medical conditions? Role of pineal melatonin interactions with the HPA axis in …

G Anderson - Melatonin Research, 2023 - melaonin-research.com
Pineal melatonin and the cortisol awakening response (CAR) are integral aspects of the
circadian rhythm. Pineal melatonin release during sleep is proposed to optimize …

Mitochondria‐associated endoplasmic reticulum membranes tethering protein VAPB‐PTPIP51 protects against ischemic stroke through inhibiting the activation of …

M Li, Y Zhang, G Yu, L Gu, H Zhu… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims Mitochondria‐associated endoplasmic reticulum membranes (MAMs) serve as a
crucial bridge connecting the endoplasmic reticulum (ER) and mitochondria within cells …

Osthole impairs mitochondrial metabolism and the autophagic flux in colorectal cancer

J Song, J Ham, W Park, G Song, W Lim - Phytomedicine, 2024 - Elsevier
Background Osthole is active constituent of Cnidium monnieri (L.) Cuss. with various
physiological functions including anti-inflammation and anti-lipedemic effects. However, the …

Bifenox induces hepatotoxicity and vascular toxicity in zebrafish embryos via ROS production and alterations in signaling pathways

H Park, T Hong, G An, J Park, G Song, W Lim - … and Physiology Part C …, 2024 - Elsevier
Existing evidence shows that currently used pesticides pose toxicological risks to exposed
wildlife. Chemically, bifenox belongs to diphenyl ethers, a well-known group of herbicides …

[HTML][HTML] Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens

E Hao, X Liu, X Chen, H Xue, B Su, Y Chen, D Wang… - Poultry Science, 2024 - Elsevier
Follicular atresia in chickens reduces the number of follicles that can further develop,
leading to decrease egg laying. Endoplasmic reticulum stress (ERS) can initiate a unique …