[HTML][HTML] Anti-Alzheimer's disease potential of traditional chinese medicinal herbs as inhibitors of BACE1 and AChE enzymes

R Dai, Y Sun, R Su, H Gao - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Alzheimer's disease (AD) is a common neurodegenerative disease that often occurs in the
elderly population. At present, most drugs for AD on the market are single-target drugs …

Techno-Functions and Safety Concerns of Plant-Based Peptides in Food Matrices

CC Lee, I Suttikhana, TJ Ashaolu - Journal of Agricultural and …, 2024 - ACS Publications
Plant-based peptides (PBPs) benefit functional food development and environmental
sustainability. Proteolysis remains the primary method of peptide production because it is a …

StructuralDPPIV: a novel deep learning model based on atom structure for predicting dipeptidyl peptidase-IV inhibitory peptides

D Wang, J Jin, Z Li, Y Wang, M Fan, S Liang… - …, 2024 - academic.oup.com
Motivation Diabetes is a chronic metabolic disorder that has been a major cause of
blindness, kidney failure, heart attacks, stroke, and lower limb amputation across the world …

In Silico Prospecting for Novel Bioactive Peptides from Seafoods: A Case Study on Pacific Oyster (Crassostrea gigas)

L Zhou, RL Mendez, JY Kwon - Molecules, 2023 - mdpi.com
Pacific oyster (Crassostrea gigas), an abundant bivalve consumed across the Pacific, is
known to possess a wide range of bioactivities. While there has been some work on its …

Recent advances in bioactive peptides from cereal-derived Foodstuffs

Q Wu, Z Guo, Z Zhou, M Jin, Q Li… - International Journal of …, 2022 - Taylor & Francis
Cereal-derived proteins account for a major part of human dietary protein consumption.
Natural bioactive peptides (NBPs) from these proteins involve a variety of physiological …

Advances in biosynthesis of peptide drugs: Technology and industrialization

J Wang, L Chen, S Qin, M Xie, SZ Luo… - Biotechnology …, 2024 - Wiley Online Library
Peptide drugs are developed from endogenous or synthetic peptides with specific biological
activities. They have advantages of strong target specificity, high efficacy and low toxicity …

Exploration of DPP-IV inhibitory peptide design rules assisted by the deep learning pipeline that identifies the restriction enzyme cutting site

C Guan, J Luo, S Li, ZL Tan, Y Wang, H Chen… - ACS …, 2023 - ACS Publications
The mining of antidiabetic dipeptidyl peptidase IV (DPP-IV) inhibitory peptides (DPP-IV-IPs)
is currently a costly and laborious process. Due to the absence of rational peptide design …

Protease-Catalyzed Rational Synthesis of Uric Acid-Lowering Peptides in Non-aqueous Medium

XN Huang, YM Zhang, Y Wen, Y Jiang… - International Journal of …, 2022 - Springer
Gout with etiological hyperuricemia deteriorates patient's quality of life, making an urgent
need for effective uric acid-lowering drugs. Uric acid-lowering peptides derived from …

[PDF][PDF] A novel attention-based peptide language model for mining dipeptidyl peptidase-IV inhibitory peptides

C Guan, J Luo, S Li, ZL Tan, J Li, Z Wu, Y Wang… - bioRxiv, 2022 - researchgate.net
Abstract 1 Dipeptidyl peptidase IV (DPP-IV) inhibitory peptides (DPP-IV-IPs) are next
generation anti-2 diabetic drugs. Only a limited number of DPP-IV-IPs have been discovered …

A novel attention-based peptide language model for dipeptidyl peptidase-IV inhibitory peptides mining

C Guan, J Luo, S Li, ZL Tan, J Li, Z Wu, Y Wang… - bioRxiv, 2022 - biorxiv.org
Abstract Dipeptidyl peptidase IV (DPP-IV) inhibitory peptides (DPP-IV-IP) are novel anti-
diabetic drugs. However, limited number of DPP-IV-IP have been discovered due to lack of …