The pathogenetic role of HLA-B27 and its subtypes

MA Khan, A Mathieu, R Sorrentino, N Akkoc - Autoimmunity reviews, 2007 - Elsevier
The strong association between HLA-B27 and ankylosing spondylitis has been known for
more than 33 years, but the enigma of the pathogenetic role of the gene and its product has …

Ankylosing spondylitis: recent developments and anaesthetic implications

LJ Woodward, PCA Kam - Anaesthesia, 2009 - Wiley Online Library
Ankylosing spondylitis can present significant challenges to the anaesthetist as a
consequence of the potential difficult airway, cardiovascular and respiratory complications …

Revisiting the arthritogenic peptide theory: quantitative not qualitative changes in the peptide repertoire of HLA–B27 allotypes

RB Schittenhelm, TCCLK Sian… - Arthritis & …, 2015 - Wiley Online Library
Objective The association of HLA–B27 with spondyloarthropathy is one of the strongest
documented for any autoimmune disease. A common hypothesis for this association is the …

Additional human β2‐microglobulin curbs HLA–B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA–B27–transgenic rats

TM Tran, ML Dorris, N Satumtira… - Arthritis & …, 2006 - Wiley Online Library
Objective Ankylosing spondylitis and related spondylarthritides are associated with HLA–
B27, and also with intestinal inflammation, by unknown mechanisms. The folded HLA–B27 …

[HTML][HTML] Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies

D Malvy, K Ezzedine, M Mamani-Matsuda… - BMC infectious …, 2009 - Springer
Background Chikungunya fever is an emerging arboviral disease characterized by an algo-
eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to …

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications

R Busch, S Kollnberger, ED Mellins - Nature Reviews Rheumatology, 2019 - nature.com
Our understanding of the mechanisms underlying HLA associations with inflammatory
arthritis continues to evolve. Disease associations have been refined, and interactions of …

Female choice and the MHC

A Ziegler, H Kentenich, B Uchanska-Ziegler - TRENDS in Immunology, 2005 - cell.com
In animals, it is the female that typically selects a mating partner. This decision can occur
before, during and after copulation. Here, recent evidence for the involvement of genes …

A review of the pathogenesis of ankylosing spondylitis

E Dakwar, J Reddy, FL Vale, JS Uribe - Neurosurgical focus, 2008 - thejns.org
✓ Ankylosing spondylitis (AS) is a chronic, progressive inflammatory rheumatic disease
involving primarily the sacroiliac joints and the axial skeleton. The main clinical features are …

Pathogenesis of ankylosing spondylitis and reactive arthritis

TH Kim, WS Uhm, RD Inman - Current opinion in rheumatology, 2005 - journals.lww.com
Pathogenesis of ankylosing spondylitis and reactive arthriti... : Current Opinion in Rheumatology
Pathogenesis of ankylosing spondylitis and reactive arthritis : Current Opinion in Rheumatology …

What is the role of HLA-B27 in spondyloarthropathies?

A Chatzikyriakidou, PV Voulgari, AA Drosos - Autoimmunity reviews, 2011 - Elsevier
HLA-B27 (Human Leukocyte Antigen-B27) accounts approximately for the one third of the
overall genetic susceptibility to spondylorthropathies (SpAs). Up to 70 HLA-B27 subtypes …