Principles and innovative technologies for decrypting noncoding RNAs: from discovery and functional prediction to clinical application
YM Sun, YQ Chen - Journal of hematology & oncology, 2020 - Springer
Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have
apparent protein-coding roles, but they have been verified to play important roles in diverse …
apparent protein-coding roles, but they have been verified to play important roles in diverse …
Recent advances in population genomics of plant-parasitic nematodes
J Montarry, B Mimee, EGJ Danchin… - …, 2021 - Am Phytopath Society
Plant-parasitic nematodes are a costly burden of crop production. Ubiquitous in nature,
phytoparasitic nematodes are associated with nearly every important agricultural crop and …
phytoparasitic nematodes are associated with nearly every important agricultural crop and …
A core set of venom proteins is released by entomopathogenic nematodes in the genus Steinernema
DZ Chang, L Serra, D Lu, A Mortazavi… - PLoS …, 2019 - journals.plos.org
Parasitic helminths release molecular effectors into their hosts and these effectors can
directly damage host tissue and modulate host immunity. Excreted/secreted proteins (ESPs) …
directly damage host tissue and modulate host immunity. Excreted/secreted proteins (ESPs) …
Single-worm long-read sequencing reveals genome diversity in free-living nematodes
Obtaining sufficient genetic material from a limited biological source is currently the primary
operational bottleneck in studies investigating biodiversity and genome evolution. In this …
operational bottleneck in studies investigating biodiversity and genome evolution. In this …
Genomic profiling of virulence in the soybean cyst nematode using single-nematode sequencing
DT Ste-Croix, AFG St-Marseille, E Lord… - …, 2021 - Am Phytopath Society
Soybean cyst nematode (SCN) is one of the most important diseases in soybean. Currently,
the main management strategy relies on planting resistant cultivars. However, the overuse of …
the main management strategy relies on planting resistant cultivars. However, the overuse of …
Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans
The intracellular level of fatty aldehydes is tightly regulated by aldehyde dehydrogenases to
minimize the formation of toxic lipid and protein adducts. Importantly, the dysregulation of …
minimize the formation of toxic lipid and protein adducts. Importantly, the dysregulation of …
SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans
The transcriptional co-regulator SIN3 influences gene expression through multiple
interactions that include histone deacetylases. Haploinsufficiency and mutations in SIN3 are …
interactions that include histone deacetylases. Haploinsufficiency and mutations in SIN3 are …
Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode
In asexual animals, female meiosis is modified to produce diploid oocytes. If meiosis still
involves recombination, this is expected to lead to a rapid loss of heterozygosity, with …
involves recombination, this is expected to lead to a rapid loss of heterozygosity, with …
Using single-worm RNA sequencing to study C. elegans responses to pathogen infection
AJ Wang, P Wibisono, BM Geppert, Y Liu - BMC genomics, 2022 - Springer
Background Caenorhabditis elegans is an excellent research model whose populations
have been used in many studies to address various biological questions. Although worm-to …
have been used in many studies to address various biological questions. Although worm-to …
Time-course swRNA-seq uncovers a hierarchical gene regulatory network in controlling the response-repair-remodeling after wounding
X Yu, J Zhou, W Ye, J Xu, R Li, L Huang, Y Chai… - Communications …, 2024 - nature.com
Wounding initiates intricate responses crucial for tissue repair and regeneration. Yet, the
gene regulatory networks governing wound healing remain poorly understood. Here …
gene regulatory networks governing wound healing remain poorly understood. Here …