Principles and innovative technologies for decrypting noncoding RNAs: from discovery and functional prediction to clinical application

YM Sun, YQ Chen - Journal of hematology & oncology, 2020 - Springer
Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have
apparent protein-coding roles, but they have been verified to play important roles in diverse …

Recent advances in population genomics of plant-parasitic nematodes

J Montarry, B Mimee, EGJ Danchin… - …, 2021 - Am Phytopath Society
Plant-parasitic nematodes are a costly burden of crop production. Ubiquitous in nature,
phytoparasitic nematodes are associated with nearly every important agricultural crop and …

A core set of venom proteins is released by entomopathogenic nematodes in the genus Steinernema

DZ Chang, L Serra, D Lu, A Mortazavi… - PLoS …, 2019 - journals.plos.org
Parasitic helminths release molecular effectors into their hosts and these effectors can
directly damage host tissue and modulate host immunity. Excreted/secreted proteins (ESPs) …

Single-worm long-read sequencing reveals genome diversity in free-living nematodes

YC Lee, HM Ke, YC Liu, HH Lee, MC Wang… - Nucleic Acids …, 2023 - academic.oup.com
Obtaining sufficient genetic material from a limited biological source is currently the primary
operational bottleneck in studies investigating biodiversity and genome evolution. In this …

Genomic profiling of virulence in the soybean cyst nematode using single-nematode sequencing

DT Ste-Croix, AFG St-Marseille, E Lord… - …, 2021 - Am Phytopath Society
Soybean cyst nematode (SCN) is one of the most important diseases in soybean. Currently,
the main management strategy relies on planting resistant cultivars. However, the overuse of …

Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans

L Zeng, X Li, CB Preusch, GJ He, N Xu… - PLoS …, 2021 - journals.plos.org
The intracellular level of fatty aldehydes is tightly regulated by aldehyde dehydrogenases to
minimize the formation of toxic lipid and protein adducts. Importantly, the dysregulation of …

SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans

VJ Robert, M Caron, L Gely, A Adrait… - …, 2023 - journals.biologists.com
The transcriptional co-regulator SIN3 influences gene expression through multiple
interactions that include histone deacetylases. Haploinsufficiency and mutations in SIN3 are …

Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode

C Blanc, N Saclier, E Le Faou, L Marie-Orleach… - Science …, 2023 - science.org
In asexual animals, female meiosis is modified to produce diploid oocytes. If meiosis still
involves recombination, this is expected to lead to a rapid loss of heterozygosity, with …

Using single-worm RNA sequencing to study C. elegans responses to pathogen infection

AJ Wang, P Wibisono, BM Geppert, Y Liu - BMC genomics, 2022 - Springer
Background Caenorhabditis elegans is an excellent research model whose populations
have been used in many studies to address various biological questions. Although worm-to …

Time-course swRNA-seq uncovers a hierarchical gene regulatory network in controlling the response-repair-remodeling after wounding

X Yu, J Zhou, W Ye, J Xu, R Li, L Huang, Y Chai… - Communications …, 2024 - nature.com
Wounding initiates intricate responses crucial for tissue repair and regeneration. Yet, the
gene regulatory networks governing wound healing remain poorly understood. Here …