Secreted frizzled-related protein 1 (SFRP1) is a gene that belongs to the secreted
glycoprotein SFRP family. SFRP1 has been classified as a tumor suppressor gene due to …

The WNT/β–catenin signaling pathway plays an important role in the differentiation and
proliferation of hematopoietic cells. In recent years, special attention has been paid to the …

Dishevelled (Dvl) is a scaffold protein that transmits Wnt signals to downstream effector
molecules via both canonical and non-canonical Wnt signaling pathways. Deregulated …

Background Hemodynamic overload causes cardiac hypertrophy leading to heart failure.
Wnt signaling pathway was reported activated in heart failure. Secreted frizzled related …

Wnt-signaling pathway plays a crucial role in the pathogenesis and progression of Chronic
Myeloid Leukemia (CML). sFRP1 is involved in the suppression of the Wnt-signaling …

Osteoporosis is a metabolic bone disease that involves gradual loss of bone density and
mass, thus resulting in increased fragility and risk of fracture. Inflammatory cytokines, such …

Wnt signaling has been a topic of research for many years for its diverse and fundamental
functions in physiological (such as embryogenesis, organogenesis, proliferation, tissue …

Background: Wnt signaling cascades play important roles in cell fate decisions and their
deregulation has been documented in many diseases, including malignant tumors and …

In Denmark approximately 1,000 individuals receive the diagnosis pancreatic ductal
adenocarcinoma (PDAC) annually. Due to its poor prognosis and increasing incidence …

Chronic myeloid leukemia is a clonal hematopoietic stem cell disease characterized by
myeloid expansion. The hallmark of the disease is the Philadelphia chromosome, which …