Mitochondrial DNA copy number in human disease: the more the better?
R Filograna, M Mennuni, D Alsina, NG Larsson - FEBS letters, 2021 - Wiley Online Library
Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …
Extreme heterogeneity of human mitochondrial DNA from organelles to populations
JB Stewart, PF Chinnery - Nature Reviews Genetics, 2021 - nature.com
Contrary to the long-held view that most humans harbour only identical mitochondrial
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …
Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers
K Chen, P Lu, NM Beeraka, OA Sukocheva… - Seminars in cancer …, 2022 - Elsevier
Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …
[HTML][HTML] Mammalian mitochondria and aging: an update
TES Kauppila, JHK Kauppila, NG Larsson - Cell metabolism, 2017 - cell.com
Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …
following decades, multiple lines of evidence in model organisms and humans showed that …
Mitochondria and cancer
Decades ago, Otto Warburg observed that cancers ferment glucose in the presence of
oxygen, suggesting that defects in mitochondrial respiration may be the underlying cause of …
oxygen, suggesting that defects in mitochondrial respiration may be the underlying cause of …
Whole genome sequencing analysis for cancer genomics and precision medicine
H Nakagawa, M Fujita - Cancer science, 2018 - Wiley Online Library
Explosive advances in next‐generation sequencer (NGS) and computational analyses have
enabled exploration of somatic protein‐altered mutations in most cancer types, with coding …
enabled exploration of somatic protein‐altered mutations in most cancer types, with coding …
Maintenance and expression of mammalian mitochondrial DNA
CM Gustafsson, M Falkenberg… - Annual review of …, 2016 - annualreviews.org
Mammalian mitochondrial DNA (mtDNA) encodes 13 proteins that are essential for the
function of the oxidative phosphorylation system, which is composed of four respiratory …
function of the oxidative phosphorylation system, which is composed of four respiratory …
Comprehensive molecular characterization of mitochondrial genomes in human cancers
Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part
of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer …
of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer …
Impact of cancer metabolism on therapy resistance–clinical implications
AC Gonçalves, E Richiardone, J Jorge, B Polónia… - Drug Resistance …, 2021 - Elsevier
Despite an increasing arsenal of anticancer therapies, many patients continue to have poor
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …
[HTML][HTML] Mitochondrial DNA is a major source of driver mutations in cancer
Mitochondrial DNA (mtDNA) mutations are among the most common genetic events in all
tumors and directly impact metabolic homeostasis. Despite the central role mitochondria …
tumors and directly impact metabolic homeostasis. Despite the central role mitochondria …