Hearing loss is the most common form of sensory impairment in humans and affects more
than 40 million people in the United States alone. No drug-based therapy has been …

Regeneration of sensory hair cells in the mature avian inner ear was first described just over
20 years ago. Since then, it has been shown that many other non-mammalian species either …

In mammals, the permanence of acquired hearing loss is mostly due to the incapacity of the
cochlea to replace lost mechanoreceptor cells, or hair cells. In contrast, damaged vestibular …

The adult mammalian cochlea lacks regenerative capacity, which is the main reason for the
permanence of hearing loss. Vestibular organs, in contrast, replace a small number of lost …

Aminoglycoside antibiotics, loop diuretics, antineoplastic agents and other commonly used
pharmacological drugs are ototoxic. Understanding of the cellular and molecular …

Mammalian hair cells do not regenerate, and their loss is a major cause of deafness. We
recently identified leucine-rich repeat containing, G-protein-coupled receptor 5 (Lgr5) …

Inner ear hair cells detect environmental signals associated with hearing, balance, and body
orientation. In humans and other mammals, significant hair cell loss leads to irreversible …

Mechanosensory hair cells (HCs) are the primary receptors of our senses of hearing and
balance. Elucidation of the transcriptional networks regulating HC fate determination and …

In mammals, hearing loss is irreversible due to the lack of regenerative potential of non-
sensory cochlear cells. Neonatal cochlear cells, however, can grow into organoids that …

Objective: To describe the internal auditory canal (IAC) and inner ear morphologic
characteristics of children with cochlear nerve (CN) deficiency. Study Design: Retrospective …