Regulation of small gtpases by gefs, gaps, and gdis
J Cherfils, M Zeghouf - Physiological reviews, 2013 - journals.physiology.org
Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …
ARF GTPases and their GEFs and GAPs: concepts and challenges
E Sztul, PW Chen, JE Casanova… - Molecular biology of …, 2019 - Am Soc Cell Biol
Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …
required to develop models of its actions in cells. Studying a protein family in the aggregate …
ARF family G proteins and their regulators: roles in membrane transport, development and disease
JG Donaldson, CL Jackson - Nature reviews Molecular cell biology, 2011 - nature.com
Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide-binding (G)
proteins, including the ARF-like (ARL) proteins and SAR1, regulate membrane traffic and …
proteins, including the ARF-like (ARL) proteins and SAR1, regulate membrane traffic and …
Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis
Synaptotagmin-1 and neuronal SNARE proteins have central roles in evoked synchronous
neurotransmitter release; however, it is unknown how they cooperate to trigger synaptic …
neurotransmitter release; however, it is unknown how they cooperate to trigger synaptic …
Myr-Arf1 conformational flexibility at the membrane surface sheds light on the interactions with ArfGAP ASAP1
Y Zhang, O Soubias, S Pant, F Heinrich, A Vogel… - Nature …, 2023 - nature.com
Abstract ADP-ribosylation factor 1 (Arf1) interacts with multiple cellular partners and
membranes to regulate intracellular traffic, organelle structure and actin dynamics. Defining …
membranes to regulate intracellular traffic, organelle structure and actin dynamics. Defining …
A structure of the COPI coat and the role of coat proteins in membrane vesicle assembly
SO Dodonova, P Diestelkoetter-Bachert, A von Appen… - Science, 2015 - science.org
Transport of material within cells is mediated by trafficking vesicles that bud from one cellular
compartment and fuse with another. Formation of a trafficking vesicle is driven by membrane …
compartment and fuse with another. Formation of a trafficking vesicle is driven by membrane …
The structure of COPI vesicles and regulation of vesicle turnover
COPI‐coated vesicles mediate transport between Golgi stacks and retrograde transport from
the Golgi to the endoplasmic reticulum. The COPI coat exists as a stable heptameric …
the Golgi to the endoplasmic reticulum. The COPI coat exists as a stable heptameric …
Assembly of COPI and COPII vesicular coat proteins on membranes
J Béthune, FT Wieland - Annual review of biophysics, 2018 - annualreviews.org
In eukaryotes, distinct transport vesicles functionally connect various intracellular
compartments. These carriers mediate transport of membranes for the biogenesis and …
compartments. These carriers mediate transport of membranes for the biogenesis and …
Construction of human activity‐based phosphorylation networks
The landscape of human phosphorylation networks has not been systematically explored,
representing vast, unchartered territories within cellular signaling networks. Although a large …
representing vast, unchartered territories within cellular signaling networks. Although a large …
9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments
SO Dodonova, P Aderhold, J Kopp, I Ganeva… - Elife, 2017 - elifesciences.org
COPI coated vesicles mediate trafficking within the Golgi apparatus and between the Golgi
and the endoplasmic reticulum. Assembly of a COPI coated vesicle is initiated by the small …
and the endoplasmic reticulum. Assembly of a COPI coated vesicle is initiated by the small …