Perineural invasion (PNI) can be found in a variety of malignant tumors. It is a sign of tumor
metastasis and invasion and portends the poor prognosis of patients. The pathological …

Neurotransmitters are conventionally viewed as nerve-secreted substances that mediate the
stimulatory or inhibitory neuronal functions through binding to their respective receptors. In …

Neuropeptide Y (NPY), an amino acid, used for various physiological processes for
management and treatment of various ailments related to central nervous system …

Neuropeptide Y (NPY) is a neuropeptide abundantly expressed in the mammalian central
and peripheral nervous system. NPY is a pleiotropic molecule, which influences cell …

Hypoxia develops during the growth of solid tumors and influences tumoral activity in
multiple ways. Low oxygen tension is also present in the bone microenvironment where …

Emerging evidence suggests that nerves within the tumor microenvironment play a crucial
role in regulating angiogenesis. Neurotransmitters and neuropeptides released by nerves …

Currently available data on the involvement of neuropeptide Y (NPY), peptide YY (PYY), and
pancreatic polypeptide (PP) and their receptors (YRs) in cancer are updated. The structure …

The tumor microenvironment (TME) plays an essential role in the development and
progression of neoplasms. TME consists of the extracellular matrix and numerous …

One of the challenges of cancer is its heterogeneity and rapid capacity to adapt.
Notwithstanding significant progress in the last decades in genomics and precision …

Abstract Purpose Neuropeptide Y (NPY) is a pleiotropic peptide, which is involved in many
biological mechanisms important in regulation of cell growth and survival. The aim of this …