Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Bone and bone marrow are among the most frequent metastatic sites of cancer. The
occurrence of bone metastasis is frequently associated with a dismal disease outcome. The …

Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their
own growth and evade chemotherapy. Here, we provide evidence that acute myeloid …

Breast cancer is the most common cancer affecting women worldwide, with bone
metastases presenting as the most common site of disease recurrence. Bone metastases …

Despite recognizing the devastating consequences of metastasis, we are not yet able to
effectively treat cancer that has spread to vital organs. The inherent complexity of genomic …

Wnt/β-catenin signaling is central to bone development and homeostasis in adulthood and
its deregulation is associated with bone pathologies. Dickkopf-1 (DKK1), a soluble inhibitor …

Abstract Background Triple Negative subset of (TN) Breast Cancers (BC), a close associate
of the basal-like subtype (with limited discordance) is an aggressive form of the disease …

The skeleton as an organ is widely distributed throughout the entire vertebrate body. Wnt
signaling has emerged to play major roles in almost all aspects of skeletal development and …

Osteosarcoma and Ewing sarcoma are the most common malignant primary bone tumors
mainly occurring in children, adolescents and young adults. Current standard therapy …

Wnt signalling is a fundamental pathway involved in embryonic development and adult
tissue homeostasis. Mutations in the pathway frequently lead to developmental defects and …