Myopia is one of the most prevalent ocular conditions and is the result of a mismatch
between the power of the eye and axial length of the eye. As a result images of distant …

Heritable disorders of connective tissue can be due to Mendelian defects in the components
of the extracellular matrix, the enzymes that perform posttranslational processing, or in the …

The lens capsule is a modified basement membrane that completely surrounds the ocular
lens. It is known that this extracellular matrix is important for both the structure and …

Mutations in the gene for fibrillin-1 (FBN1) have been shown to cause Marfan syndrome, an
autosomal dominant disorder of connective tissue characterised by pleiotropic …

The ADAMTS (ad isintegrin-like and metalloproteinase domain with thrombospondin-type 1
motifs) protein superfamily includes 19 secreted metalloproteases and 7 secreted ADAMTS …

Marfan syndrome is a widespread disorder of connective tissue. It is characterized by
systemic and ocular features due to mutations in the fibrillin gene. Awareness and prompt …

Marfan syndrome (MFS) is an autosomal dominant, age-related but highly penetrant
condition with substantial intrafamilial and interfamilial variability. MFS is caused by …

Abstract" The Diseases of the Horny-coat of The Eye", known today as keratoconus, is a
progressive, multifactorial, non-inflammatory ectatic corneal disorder that is characterized by …

purpose. To examine ultrastructurally the composition of extracellular matrix (ECM)
materials, the distribution of myocilin, and the colocalization of myocilin with ECM …

Evidence in the recent literature has highlighted the importance of central corneal thickness
(CCT) in relation to several ocular and non-ocular conditions. Most notably, thinner CCT has …