[HTML][HTML] Major molecular signaling pathways in oral cancer associated with therapeutic resistance

S Usman, A Jamal, MT Teh, A Waseem - Frontiers in Oral Health, 2021 - frontiersin.org
Oral cancer is a sub-category of head and neck cancers that primarily initiates in the oral
cavity. The primary treatment option for oral cancer remains surgery but it is associated with …

[HTML][HTML] Cisplatin induces autophagy-associated apoptosis in human oral squamous cell carcinoma (OSCC) mediated in part through reactive oxygen species

S Magnano, PH Barroeta, R Duffy, J O'Sullivan… - Toxicology and applied …, 2021 - Elsevier
Abstract Oral Squamous Cell Carcinoma (OSCC) is the sixth most common cancer
worldwide. Chemoresistance is a critical problem in OSCC leading to therapeutic failure and …

[HTML][HTML] Autophagy in aging-related oral diseases

D Peña-Oyarzún, C San Martin… - Frontiers in …, 2022 - frontiersin.org
Autophagy is an intracellular degradation mechanism that allows recycling of organelles
and macromolecules. Autophagic function increases metabolite availability modulating …

[HTML][HTML] Oxidative stress and autophagy mediate anti-cancer properties of cannabis derivatives in human oral cancer cells

L Loubaki, M Rouabhia, MA Zahrani, AA Amri… - Cancers, 2022 - mdpi.com
Simple Summary The legalization of cannabis in 2018 in Canada has generated a heated
public debate. The subject is complex, controversial, and completely opposite currents of …

[HTML][HTML] High expression of HSP60 and survivin predicts poor prognosis for oral squamous cell carcinoma patients

Y Zhou, Y Tang, J Luo, Y Yang, H Zang, J Ma, S Fan… - BMC Oral Health, 2023 - Springer
Background HSP60 is a heat shock proteins (HSPs) family member and help mitochondrial
protein to fold correctly. Survivin is one of the inhibitors of apoptosis protein family member …

[HTML][HTML] Peroxiredoxin 1 regulates crosstalk between pyroptosis and autophagy in oral squamous cell carcinoma leading to a potential pro-survival

M Ye, T Liu, S Liu, R Tang, H Liu, F Zhang, S Luo… - Cell Death …, 2023 - nature.com
Abstract Peroxiredoxin 1 (Prdx1), a vital antioxidant enzyme, has been proven to play an
important role in the occurrence and development of cancers, but its effects on oral …

[HTML][HTML] Mild Salinity Stimulates Biochemical Activities and Metabolites Associated with Anticancer Activities in Black Horehound (Ballota nigra L.)

M Younessi-Hamzekhanlu, Z Dibazarnia, S Oustan… - Agronomy, 2021 - mdpi.com
Black horehound (Ballota nigra L.) is one of the most important medicinal plants, as a rich
source of health-promoting essential oils and metabolites. Salinity stress affects plant …

Tanshinone IIa induces autophagy and apoptosis via PI3K/Akt/mTOR Axis in acute promyelocytic leukemia NB4 cells

Y Pan, L Chen, R Li, Y Liu, M Nan… - … and Alternative Medicine, 2021 - Wiley Online Library
Tanshinone IIa (TanIIa), an ingredient of Radix Salviae Miltiorrhizae, has an anticancer
effect on various solid tumors with high efficiency and low toxicity. Nonetheless, the …

[HTML][HTML] Epigenetic dysregulation in autophagy signaling as a driver of viral manifested oral carcinogenesis

S Patra, S Patil, S Das, SK Bhutia - … Acta (BBA)-Molecular Basis of Disease, 2022 - Elsevier
Background Concurrent viral infections insist on dysregulated epigenetics of tumor
suppressor genes (TSGs), cell cycle regulators, apoptosis, and autophagy-associated genes …

Autophagy inhibition enhances anti‐pituitary adenoma effect of tetrandrine

L Lyu, Y Hu, S Yin, L Wang, F Ye, M Wang… - Phytotherapy …, 2021 - Wiley Online Library
Pituitary adenoma (PA) is a benign intracranial neoplasm originated from pituitary gland.
Surgery is the first‐line therapy for most of PAs, but lead to unsatisfactory prognosis in some …