Single cell genomics has become a popular approach to uncover the cellular heterogeneity
of progenitor and terminally differentiated cell types with great precision. This approach can …

Metastasis and tumor progression are the major cause of death in patients suffering from
pancreatic ductal adenocarcinoma. Tumor growth and especially dissemination are typically …

In vitro differentiation of human stem cells can produce pancreatic β-cells; the loss of this
insulin-secreting cell type underlies type 1 diabetes. Here, as a step towards understanding …

Understanding pancreas development can provide clues for better treatments of pancreatic
diseases. However, the molecular heterogeneity and developmental trajectory of the early …

Human pluripotent stem cells differentiated to insulin-secreting β cells (SC-β cells) in islet
organoids could provide an unlimited cell source for diabetes cell replacement therapy …

It has generally proven challenging to produce functional β cells in vitro. Here, we describe a
previously unidentified protein C receptor positive (Procr+) cell population in adult mouse …

Deciphering mechanisms of endocrine cell induction, specification and lineage allocation in
vivo will provide valuable insights into how the islets of Langerhans are generated …

Human embryonic stem cells (hESCs) are a potential unlimited source of insulin-producing
β cells for diabetes treatment. A greater understanding of how β cells form during embryonic …

Islet gene expression has been widely studied to better understand the transcriptional
features that define a healthy β-cell. Transcriptomes of FACS-purified α-, β-, and δ-cells …

Single-cell genomics technologies enable multimodal profiling of millions of cells across
temporal and spatial dimensions. Experimental limitations prevent the measurement of all …