The mammalian Sirtuins (SIRT1-7) are an evolutionarily conserved family of NAD+-
dependent deacylase and mono-ADP-ribosyltransferase. Sirtuins display distinct subcellular …

Objective: The aim of the study was to compare the impact of 6 weeks of reducing daily
caloric intake by 20% of total daily energy expenditure (TDEE)-CRI vs. reducing daily caloric …

Insulin resistance (IR) is a state of decreased sensitivity or responsiveness of target tissues
to metabolic actions of circulating insulin. IR can be selective, involving only certain aspects …

[Purpose] The purpose of this study was to investigate the effect of exercise and dietary
change on obesity and insulin resistance and mTOR signaling protein levels in skeletal …

Background: Gestational diabetes mellitus (GDM) has long-lasting influence on offspring,
which is associated with increased risks of insulin resistance, obesity, and type II diabetes …

Background: Open vascular surgery interventions are not infrequently hampered by
complication rates and durability. Preclinical surgical models show promising beneficial …

IN BRIEF This study explored the impact of correcting vitamin D deficiency on blood
pressure, metabolic status, and weight loss in patients with fatigue and obesity refractory to …

It has been known for almost a century that caloric restriction can extend the life span of
rodents and many other types of animals. Approximately 25 years ago, it was found that a …

The incidence of obesity and type 2 diabetes (T2D) are increasing in the UK and there is
evidencethat these disorders influence the ageing process. The mechanisms by which …