Identification of RNA structures and their roles in RNA functions
The development of high-throughput RNA structure profiling methods in the past decade has
greatly facilitated our ability to map and characterize different aspects of RNA structures …
greatly facilitated our ability to map and characterize different aspects of RNA structures …
RNA G-quadruplexes and stress: emerging mechanisms and functions
RNA G-quadruplexes (rG4s) are noncanonical secondary structures formed by guanine-rich
sequences that are found in different regions of RNA molecules. These structures have been …
sequences that are found in different regions of RNA molecules. These structures have been …
G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes
G Giraud, M Rodà, P Huchon, M Michelet… - Nucleic Acids …, 2024 - academic.oup.com
Phase separation regulates fundamental processes in gene expression and is mediated by
the local concentration of proteins and nucleic acids, as well as nucleic acid secondary …
the local concentration of proteins and nucleic acids, as well as nucleic acid secondary …
Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase
AC Papageorgiou, M Pospisilova, J Cibulka… - Nature …, 2023 - nature.com
Biomolecular polyelectrolyte complexes can be formed between oppositely charged
intrinsically disordered regions (IDRs) of proteins or between IDRs and nucleic acids. Highly …
intrinsically disordered regions (IDRs) of proteins or between IDRs and nucleic acids. Highly …
Tuning Material States and Functionalities of G-Quadruplex-Modulated RNA-Peptide Condensates
RNA encodes sequence-and structure-dependent interactions to modulate the assembly
and properties of biomolecular condensates. RNA G-quadruplexes (rG4s) formed by …
and properties of biomolecular condensates. RNA G-quadruplexes (rG4s) formed by …
Single-molecular dissection of liquid–liquid phase transitions
Interaction between peptides and nucleic acids is a ubiquitous process that drives many
cellular functions, such as replications, transcriptions, and translations. Recently, this …
cellular functions, such as replications, transcriptions, and translations. Recently, this …
Liquid-liquid phase separation (LLPS) in DNA and chromatin systems from the perspective of colloid physical chemistry
DNA is a highly charged polyelectrolyte and is prone to associative phase separation driven
by the presence of multivalent cations, charged surfactants, proteins, polymers and colloids …
by the presence of multivalent cations, charged surfactants, proteins, polymers and colloids …
G-quadruplexes promote the motility in MAZ phase-separated condensates to activate CCND1 expression and contribute to hepatocarcinogenesis
W Wang, D Li, Q Xu, J Cheng, Z Yu, G Li, S Qiao… - Nature …, 2024 - nature.com
Abstract G-quadruplexes (G4s) can recruit transcription factors to activate gene expression,
but detailed mechanisms remain enigmatic. Here, we demonstrate that G4s in the CCND1 …
but detailed mechanisms remain enigmatic. Here, we demonstrate that G4s in the CCND1 …
Controlling liquid–liquid phase separation of G-quadruplex-forming RNAs in a sequence-specific manner
M Tsuruta, T Torii, K Kohata, K Kawauchi… - Chemical …, 2022 - pubs.rsc.org
We constructed a minimum liquid–liquid phase separation model system to form liquid
droplets using only G-quadruplex-forming oligonucleotides and R-and G-rich oligopeptides …
droplets using only G-quadruplex-forming oligonucleotides and R-and G-rich oligopeptides …
Liquid–liquid crystalline phase separation in biomolecular solutions
TP Fraccia, G Zanchetta - Current Opinion in Colloid & Interface Science, 2021 - Elsevier
Liquid–liquid phase separation (LLPS) and liquid crystalline (LC) ordering are ubiquitous
phenomena in nature, in a variety of biomolecular solutions. Here, we review instances in …
phenomena in nature, in a variety of biomolecular solutions. Here, we review instances in …