During transcription, the nascent RNA strand can base pair with its template DNA, displacing
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …

Precise spatio–temporal control of gene activity is essential for organismal development,
growth, and survival in a changing environment. Decisive steps in gene regulation involve …

Oncogene activation disturbs cellular processes and accommodates a complex landscape
of changes in the genome that contribute to genomic instability, which accelerates mutation …

R-loops have both positive and negative impacts on chromosome functions. To identify toxic
R-loops in the human genome, here, we map RNA: DNA hybrids, replication stress markers …

G quadruplexes (G4s) and R loops are noncanonical DNA structures that can regulate basic
nuclear processes and trigger DNA damage, genome instability, and cell killing. By different …

Ataxia with oculomotor apraxia 2 (AOA-2) and amyotrophic lateral sclerosis (ALS4) are
neurological disorders caused by mutations in the gene encoding for senataxin (SETX), a …

R-loop, a three-stranded RNA/DNA structure, has been linked to induced genome instability
and regulated gene expression. To enable precision analysis of R-loops in vivo, we develop …

Hepatocellular carcinoma (HCC) is the most frequent subtype of primary liver cancer and
one of the leading causes of cancer-related death worldwide. However, the molecular …

In eukaryotes, three-dimensional genome organization is critical for transcriptional
regulation of gene expression. Long noncoding RNAs (lncRNAs) can modulate chromatin …

Protein-coding and noncoding genes in eukaryotes are typically expressed as linear
messenger RNAs, with exons arranged colinearly to their genomic order. Recent advances …