An approach to measuring colistin plasma levels regarding the treatment of multidrug-resistant bacterial infection
T Pacheco, RH Bustos, D González, V Garzón… - Antibiotics, 2019 - mdpi.com
Antimicrobial resistance to antibiotic treatment has significantly increased during recent
years, causing this to become a worldwide public health problem. More than 70% of …
years, causing this to become a worldwide public health problem. More than 70% of …
[HTML][HTML] Insertion sequence mediating mrgB disruption is the major mechanism of polymyxin resistance in carbapenem-resistant Klebsiella pneumoniae isolates from …
X Chen, P Li, Z Sun, X Xu, J Jiang, J Su - Journal of Global Antimicrobial …, 2022 - Elsevier
Objectives Infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) pose
a huge health challenge worldwide. The aim of this study was to evaluate the incidence of …
a huge health challenge worldwide. The aim of this study was to evaluate the incidence of …
Emergence of a ST307 clone carrying a novel insertion element MITEKpn1 in the mgrB gene among carbapenem-resistant Klebsiella pneumoniae from Moscow …
OV Shamina, OA Kryzhanovskaya, AV Lazareva… - International journal of …, 2020 - Elsevier
Carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a major nosocomial
pathogen with only a few antimicrobial agents, including colistin, remaining active. However …
pathogen with only a few antimicrobial agents, including colistin, remaining active. However …
Distinctive Mobile Genetic Elements Observed in the Clonal Expansion of Carbapenem-Resistant Klebsiella pneumoniae in India
C Shankar, JJ Jacob, SG Sugumar… - Microbial Drug …, 2021 - liebertpub.com
Background: Klebsiella pneumoniae (Kp), a common multidrug-resistant pathogen, causes
a wide spectrum of nosocomial infections with high rates of morbidity and mortality. The …
a wide spectrum of nosocomial infections with high rates of morbidity and mortality. The …
Genetic diversity of polymyxin-resistance mechanisms in clinical isolates of carbapenem-resistant Klebsiella pneumoniae: a multicenter study in China
Z Li, X Liu, Z Lei, C Li, F Zhang, Y Wu… - Microbiology …, 2023 - Am Soc Microbiol
Polymyxin has been the last resort to treat multidrug-resistant Klebsiella pneumonia.
However, recent studies have revealed that polymyxin-resistant carbapenem-resistant …
However, recent studies have revealed that polymyxin-resistant carbapenem-resistant …
Intracellular transposition and capture of Mobile genetic elements following intercellular conjugation of multidrug resistance conjugative plasmids from clinical …
S Tansirichaiya, RN Goodman, X Guo… - Microbiology …, 2022 - Am Soc Microbiol
Mobile genetic elements (MGEs) are often associated with antimicrobial resistance genes
(ARGs). They are responsible for intracellular transposition between different replicons and …
(ARGs). They are responsible for intracellular transposition between different replicons and …
Presence of Colistin- and Tigecycline-Resistant Klebsiella pneumoniae ST29 in Municipal Wastewater Influents in Japan
W Hayashi, M Iimura, E Soga, S Koide… - Microbial Drug …, 2021 - liebertpub.com
The aim of this study was to investigate the presence of colistin-and/or tigecycline-resistant
Klebsiella spp. in influents from four wastewater treatment plants (WWTPs), which partly …
Klebsiella spp. in influents from four wastewater treatment plants (WWTPs), which partly …
Disruption of mgrB gene by IS kpn14 sourced from a bla KPC− 2 carrying plasmid mediating polymyxin resistance against carbapenem-resistant Klebsiella …
Z Li, Z Lei, X Liu, F Zhang, X Yang, Y Wu, C Li, J Zhao… - BMC microbiology, 2024 - Springer
Abstract Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections
poses global challenges, with limited options available for targeted therapy. Polymyxin was …
poses global challenges, with limited options available for targeted therapy. Polymyxin was …
Within-host acquisition of colistin-resistance of an NDM-producing Klebsiella quasipneumoniae subsp. similipneumoniae strain through the insertion sequence-903B-mediated …
Y Wu, J Zhao, Z Li, X Liu, Y Hu, F Zhang… - Frontiers in Cellular …, 2023 - frontiersin.org
Background Colistin, as the antibiotic of “last resort” for carbapenem-resistant Klebsiella,
develop resistance during administration of this antimicrobial agent. We identified an NDM-1 …
develop resistance during administration of this antimicrobial agent. We identified an NDM-1 …
Genetic Alterations Associated with Polymyxin B Resistance in Nosocomial KPC-2-Producing Klebsiella pneumoniae from Brazil
PA Campos, B Fuga, ML Ferreira… - Microbial Drug …, 2021 - liebertpub.com
The rapid increased multidrug resistance in Klebsiella pneumoniae has led to a renewed
interest in polymyxin antibiotics, such as colistin, as antibiotics of last resort, not least in …
interest in polymyxin antibiotics, such as colistin, as antibiotics of last resort, not least in …