Premature ovarian insufficiency (POI) is the loss of normal ovarian function before the age of
40 years, a condition that affects approximately 1% of women under 40 years old and 0.1 …

Premature ovarian insufficiency (POI) is highly heterogeneous in genetic etiology. Yet
identifying causative genes has been challenging with candidate gene approaches. Recent …

The genetic etiology of premature ovarian insufficiency (POI) has been well established to
date, however, the role of long noncoding RNAs (lncRNAs) in POI is largely unknown. In this …

Blood-brain barrier (BBB) function deteriorates during aging, contributing to cognitive
impairment and neurodegeneration. It is unclear what drives BBB leakage in aging and how …

The female reproductive system is of great significance to women's health. Aging of the
female reproductive system occurs approximately 10 years prior to the natural age …

Infertility impacts a considerable number of women worldwide, and it affects different aspects
of family life and society. Although female infertility is known as a multifactorial disorder …

Premature ovarian insufficiency (POI) is defined as a loss of ovarian function before the age
of 40 years, with a prevalence rate estimated at approximately 1%. It causes infertility and is …

Problem Premature ovarian insufficiency (POI) imposes great challenge on female
reproduction. Whether immune disturbance in ovarian environment was implicated in POI …

Background Premature ovarian insufficiency (POI) is an important cause of infertility
characterized by the functional decline of the ovary. Granulosa cells (GCs) around oocytes …

Although only a small number of primordial follicles are known to be selectively activated
during female reproductive cycles, the mechanisms that trigger this recruitment remain …