High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte
trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Over the past decade, a series of discoveries relating to fibroblastic reticular cells (FRCs)—
immunologically specialized myofibroblasts found in lymphoid tissue—has promoted these …

The blood vasculature regulates both the development and function of secondary lymphoid
organs by providing a portal for entry of hemopoietic cells. During the development of …

Bronchus-associated lymphoid tissue (BALT) was originally described as a mucosal
lymphoid organ in the lungs of some species. However, while the lungs of naive mice and …

The past two decades have led to a tremendous work on the transcription factor NF-κB and
its molecular mechanisms of activation. The nuclear translocation of NF-κB is controlled by …

The lack of sufficient intratumoral CD8+ T lymphocytes is a significant obstacle to effective
immunotherapy in cancer. High endothelial venules (HEVs) are organ-specific and …

Secondary lymphoid organs (SLOs) include lymph nodes, spleen, Peyer's patches, and
mucosal tissues such as the nasal-associated lymphoid tissue, adenoids, and tonsils. Less …

Bronchus-associated lymphoid tissue (BALT) is a constitutive mucosal lymphoid tissue
adjacent to major airways in some mammalian species, including rats and rabbits, but not …

High-endothelial venules (HEVs) are specialized blood vessels allowing recirculation of
naive lymphocytes through lymphoid organs. Here, using full-length, single-cell RNA …