[HTML][HTML] Therapeutic host-directed strategies to improve outcome in tuberculosis
Abstract Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but
has limited efficacy against pulmonary TB disease development and modest protection …
has limited efficacy against pulmonary TB disease development and modest protection …
The pathogenesis of tuberculous meningitis
AG Davis, UK Rohlwink, A Proust… - Journal of leukocyte …, 2019 - academic.oup.com
Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …
Host-directed therapies: modulating inflammation to treat tuberculosis
Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB), most human hosts are able to contain the infection and avoid progression to active TB …
(TB), most human hosts are able to contain the infection and avoid progression to active TB …
The immune mechanisms of lung parenchymal damage in tuberculosis and the role of host-directed therapy
Impaired lung function is common in people with a history of tuberculosis. Host-directed
therapy added to tuberculosis treatment may reduce lung damage and result in improved …
therapy added to tuberculosis treatment may reduce lung damage and result in improved …
Targeting molecular inflammatory pathways in granuloma as host-directed therapies for tuberculosis
Globally, more than 10 million people developed active tuberculosis (TB), with 1.4 million
deaths in 2020. In addition, the emergence of drug-resistant strains in many regions of the …
deaths in 2020. In addition, the emergence of drug-resistant strains in many regions of the …
The interplay between systemic inflammation, oxidative stress, and tissue remodeling in tuberculosis
EP Amaral, CL Vinhaes… - Antioxidants & redox …, 2021 - liebertpub.com
Significance: Excessive and prolonged proinflammatory responses are associated with
oxidative stress, which is commonly observed during chronic tuberculosis (TB). Such …
oxidative stress, which is commonly observed during chronic tuberculosis (TB). Such …
Neutrophils in tuberculosisâ   first line of defence or booster of disease and targets for host-directed therapy?
T Dallenga, UE Schaible - FEMS Pathogens and Disease, 2016 - academic.oup.com
Necrotizing granulomas, exacerbating pathogenesis and neutrophil influx at the site of
infection are hallmarks of active pulmonary tuberculosis (TB) in humans. The role of …
infection are hallmarks of active pulmonary tuberculosis (TB) in humans. The role of …
Inhibition of host PARP1 contributes to the anti-inflammatory and antitubercular activity of pyrazinamide
The antibiotic pyrazinamide (PZA) is a cornerstone of tuberculosis (TB) therapy that shortens
treatment durations by several months despite being only weakly bactericidal. Intriguingly …
treatment durations by several months despite being only weakly bactericidal. Intriguingly …
Tuberculosis: an update on pathophysiology, molecular mechanisms of drug resistance, newer anti-TB drugs, treatment regimens and host-directed therapies
P Borah, PK Deb, KN Venugopala… - Current Topics in …, 2021 - ingentaconnect.com
Human tuberculosis (TB) is primarily caused by Mycobacterium tuberculosis (Mtb) that
inhabits inside and amidst immune cells of the host with adapted physiology to regulate …
inhabits inside and amidst immune cells of the host with adapted physiology to regulate …
Recent advances in host-directed therapies for tuberculosis and malaria
KC Matteucci, AAS Correa, DL Costa - Frontiers in Cellular and …, 2022 - frontiersin.org
Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, and malaria,
caused by parasites from the Plasmodium genus, are two of the major causes of death due …
caused by parasites from the Plasmodium genus, are two of the major causes of death due …