Targeting angiogenesis in oncology, ophthalmology and beyond

Y Cao, R Langer, N Ferrara - Nature Reviews Drug Discovery, 2023 - nature.com
Angiogenesis is an essential process in normal development and in adult physiology, but
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …

[HTML][HTML] Diabetic retinopathy: current understanding, mechanisms, and treatment strategies

EJ Duh, JK Sun, AW Stitt - JCI insight, 2017 - ncbi.nlm.nih.gov
Diabetic retinopathy (DR) causes significant visual loss on a global scale. Treatments for the
vision-threatening complications of diabetic macular edema (DME) and proliferative diabetic …

Pivotal trial of an autonomous AI-based diagnostic system for detection of diabetic retinopathy in primary care offices

MD Abràmoff, PT Lavin, M Birch, N Shah… - NPJ digital medicine, 2018 - nature.com
Artificial Intelligence (AI) has long promised to increase healthcare affordability, quality and
accessibility but FDA, until recently, had never authorized an autonomous AI diagnostic …

Diabetic retinopathy preferred practice pattern®

CJ Flaxel, RA Adelman, ST Bailey, A Fawzi, JI Lim… - …, 2020 - aaojournal.org
Background: Diabetic retinopathy is a leading cause of visual impairment in working-age
adults worldwide. Duration of diabetes is a major risk factor associated with the development …

Diabetic retinopathy: global prevalence, major risk factors, screening practices and public health challenges: a review

DSW Ting, GCM Cheung… - Clinical & experimental …, 2016 - Wiley Online Library
Diabetes retinopathy (DR) is a leading cause of vision loss in middle‐aged and elderly
people globally. Early detection and prompt treatment allow prevention of diabetes‐related …

Ten years of anti-vascular endothelial growth factor therapy

N Ferrara, AP Adamis - Nature reviews Drug discovery, 2016 - nature.com
The targeting of vascular endothelial growth factor A (VEGFA), a crucial regulator of both
normal and pathological angiogenesis, has revealed innovative therapeutic approaches in …

The evolving treatment of diabetic retinopathy

SE Mansour, DJ Browning, K Wong… - Clinical …, 2020 - Taylor & Francis
Purpose To review the current therapeutic options for the management of diabetic
retinopathy (DR) and diabetic macular edema (DME) and examine the evidence for …

The oxidative stress and mitochondrial dysfunction during the pathogenesis of diabetic retinopathy

MY Wu, GT Yiang, TT Lai, CJ Li - Oxidative medicine and …, 2018 - Wiley Online Library
Diabetic retinopathy is one of the most serious microvascular complications induced by
hyperglycemia via five major pathways, including polyol, hexosamine, protein kinase C, and …

Diabetic macular oedema

GS Tan, N Cheung, R Simó, GCM Cheung… - The lancet Diabetes & …, 2017 - thelancet.com
Diabetic macular oedema, characterised by exudative fluid accumulation in the macula, is
the most common form of sight-threatening retinopathy in people with diabetes. It affects one …

Evaluation and care of patients with diabetic retinopathy

LM Jampol, AR Glassman, J Sun - New England Journal of …, 2020 - Mass Medical Soc
Care of Patients with Diabetic Retinopathy Diabetic retinopathy is a leading cause of both
moderate and severe vision loss worldwide. Over the past decade, advances in technology …