Accelerated reaction kinetics in microdroplets: Overview and recent developments

Z Wei, Y Li, RG Cooks, X Yan - Annual Review of Physical …, 2020 - annualreviews.org
Various organic reactions, including important synthetic reactions involving C–C, C–N, and
C–O bond formation as well as reactions of biomolecules, are accelerated when the …

Mass spectrometry-based protein footprinting for higher-order structure analysis: fundamentals and applications

XR Liu, MM Zhang, ML Gross - Chemical reviews, 2020 - ACS Publications
Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Strong electric field observed at the interface of aqueous microdroplets

H Xiong, JK Lee, RN Zare, W Min - The journal of physical …, 2020 - ACS Publications
Chemical reactions in aqueous microdroplets often exhibit unusual kinetic and
thermodynamic properties not observed in bulk solution. While an electric field has been …

Capture of hydroxyl radicals by hydronium cations in water microdroplets

D Xing, Y Meng, X Yuan, S Jin, X Song… - Angewandte …, 2022 - Wiley Online Library
Despite the high stability of bulk water, water microdroplets possess strikingly different
properties, such as the presence of hydroxyl radicals (OH⋅) at the air–water interface …

Harnessing the high interfacial electric fields on water microdroplets to accelerate Menshutkin reactions

Z Song, C Liang, K Gong, S Zhao, X Yuan… - Journal of the …, 2023 - ACS Publications
Even though it is still an emerging field, the application of a high external electric field (EEF)
as a green and efficient catalyst in synthetic chemistry has recently received significant …

A critical analysis of electrospray techniques for the determination of accelerated rates and mechanisms of chemical reactions in droplets

G Rovelli, MI Jacobs, MD Willis, RJ Rapf… - Chemical …, 2020 - pubs.rsc.org
Electrospray and Electrosonic Spray Ionization Mass Spectrometry (ESI-MS and ESSI-MS)
have been widely used to report evidence that many chemical reactions in micro-and nano …

Abiotic production of sugar phosphates and uridine ribonucleoside in aqueous microdroplets

I Nam, JK Lee, HG Nam… - Proceedings of the …, 2017 - National Acad Sciences
Phosphorylation is an essential chemical reaction for life. This reaction generates
fundamental cell components, including building blocks for RNA and DNA, phospholipids for …

Spontaneous formation of gold nanostructures in aqueous microdroplets

JK Lee, D Samanta, HG Nam, RN Zare - Nature communications, 2018 - nature.com
The synthesis of gold nanostructures has received widespread attention owing to many
important applications. We report the accelerated synthesis of gold nanoparticles (AuNPs) …

Ultrafast enzymatic digestion of proteins by microdroplet mass spectrometry

X Zhong, H Chen, RN Zare - Nature communications, 2020 - nature.com
Enzymatic digestion for protein sequencing usually requires much time, and does not
always result in high sequence coverage. Here we report the use of aqueous microdroplets …

The role of analyte concentration in accelerated reaction rates in evaporating droplets

CJ Chen, ER Williams - Chemical science, 2023 - pubs.rsc.org
Accelerated reactions in microdroplets have been reported for a wide range of reactions with
some microdroplet reactions occurring over a million times faster than the same reaction in …