Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic disease of the lung that is marked by
progressive decline in pulmonary function and ultimately respiratory failure. Genetic and …

Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily* | Endocrine Reviews | Oxford
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Myofibroblasts are a unique group of smooth-muscle-like fibroblasts that have a similar
appearance and function regardless of their tissue of residence. Through the secretion of …

Connective tissue growth factor (CTGF) is a cysteine‐rich peptide synthesized and secreted
by fibroblastic cells after activation with transforming growth factor beta (TGF‐β) that acts as …

Connective tissue growth factor (CTGF) is a cysteine-rich protein induced by transforming
growth factor beta (TGF-β) in connective tissue cells. CTGF can trigger many of the cellular …

Connective Tissue Growth Factor/Cysteine- Rich 61/Nephroblastoma Overexpressed (CCN)
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Connective tissue growth factor (CTGF) is a member of the recently described CCN gene
family which contains CTGF itself, cyr61, nov, elm1, Cop1, and WISP-3. CTGF is …

Accumulation of mesangial matrix is a pivotal event in the pathophysiology of diabetic
nephropathy. The molecular triggers for matrix production are still being defined. Here …

Fibroblast proliferation, differentiation into myofibroblasts, and increased collagen synthesis
are key events during both normal wound repair and fibrotic lesion formation. Here we report …

Connective tissue growth factor (CTGF= CCN2), one of six members of cysteine‐rich,
secreted, heparin‐binding proteins with a modular structure, is recognized as an important …