SUMOylation is a reversible post-translational modification which has emerged as a crucial
molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune …

Post-translational protein modification by small ubiquitin-like modifier (SUMO), termed
sumoylation, is an important mechanism in cellular responses to stress and one that …

Sumoylation is an essential post‐translational modification intimately involved in a diverse
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …

Mapping the chromosomal locations of transcription factors, nucleosomes, histone
modifications, chromatin remodeling enzymes, chaperones, and polymerases is one of the …

Modification of the histone proteins associated with DNA is an important process in the
epigenetic regulation of DNA structure and function. There are several known modifications …

Understanding general principles that safeguard cellular identity should reveal critical
insights into common mechanisms underlying specification of varied cell types. Here, we …

One major role of the eukaryotic peptidic post-translational modifier SUMO in the cell is
transcriptional control. This occurs via modification of virtually all classes of transcriptional …

Clinical neurologists and scientists who study multiple sclerosis face open questions
regarding the integration of epidemiological data with genome-wide association studies and …

Transcription factors (TFs) are among the most frequently detected targets of sumoylation,
and effects of the modification have been studied for about 200 individual TFs to date. TF …

Genotoxicants have been used for decades as front-line therapies against cancer on the
basis of their DNA-damaging actions. However, some of their non-DNA-damaging effects …