▪ Abstract Cyclin-dependent kinases (Cdks) play a well-established role in the regulation of
the eukaryotic cell division cycle and have also been implicated in the control of gene …

Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a
crucial regulator of neuronal migration in the developing central nervous system. CDK5 …

Abnormal hyperphosphorylation of tau is believed to lead to neurofibrillary degeneration in
Alzheimer's disease (AD) and other tauopathies. Recent studies have shown that protein …

Hyperphosphorylation of microtubule-associated protein tau is one of the major pathological
events in Alzheimer's disease (AD) and other related neurodegenerative diseases, including …

Cyclin-dependent kinase 5 (Cdk5) is a multifaceted serine/threonine kinase protein with
important roles in the nervous system. Two related proteins, p35 and p39, activate Cdk5 …

Cyclin-dependent kinase 5 (CDK5) protein plays an important role not only in the central
nervous system but also in the periphery, including immune response, regulation of insulin …

Cyclin-dependent kinase 5 (CDK5) is a unique CDK, the activity of which can be detected in
postmitotic neurons. To date, CDK5 purified from mammalian brains has always been …

CDK5 plays an indispensable role in the central nervous system, and its deregulation is
involved in neurodegeneration. We report the crystal structure of a complex between CDK5 …

Neuronal Cdc2-like kinase is a heterodimer of Cdk5 and a 25-kDa subunit that is derived
from a 35-kDa brain-and neuron-specific protein called the neuronal Cdk5 activator …

Adults with Down syndrome (DS) develop Alzheimer neurofibrillary degeneration in the
brain, but the underlying molecular mechanism is unknown. Here, we report that the …