Role of cholinergic signaling in Alzheimer's disease

ZR Chen, JB Huang, SL Yang, FF Hong - Molecules, 2022 - mdpi.com
Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal
transduction related to memory and learning ability. Alzheimer's disease (AD), a progressive …

Molecular targets of manganese-induced neurotoxicity: A five-year update

AA Tinkov, MMB Paoliello, AN Mazilina… - International journal of …, 2021 - mdpi.com
Understanding of the immediate mechanisms of Mn-induced neurotoxicity is rapidly
evolving. We seek to provide a summary of recent findings in the field, with an emphasis to …

Consequences of disturbing manganese homeostasis

J Baj, W Flieger, A Barbachowska, B Kowalska… - International Journal of …, 2023 - mdpi.com
Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …

Environmental influence on neurodevelopmental disorders: Potential association of heavy metal exposure and autism

OM Ijomone, NF Olung, GT Akingbade… - Journal of Trace …, 2020 - Elsevier
Environmental factors have been severally established to play major roles in the
pathogenesis of neurodevelopmental disorders including autism spectrum disorder (ASD) …

Manganese in the diet: bioaccessibility, adequate intake, and neurotoxicological effects

AC Martins, BN Krum, L Queirós… - Journal of agricultural …, 2020 - ACS Publications
Manganese (Mn) is an essential element that participates in several biological processes.
Mn serves as a cofactor for several enzymes, such as glutamine synthetase and …

Manganese-induced neurodegenerative diseases and possible therapeutic approaches

AC Martins Jr, P Gubert, GR Villas Boas… - Expert review of …, 2020 - Taylor & Francis
Introduction Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's
disease, Huntington's disease, amyotrophic lateral sclerosis and prion disease represent …

New insights on the role of manganese in Alzheimer's disease and Parkinson's disease

AC Martins Jr, P Morcillo, OM Ijomone… - International journal of …, 2019 - mdpi.com
Manganese (Mn) is an essential trace element that is naturally found in the environment and
is necessary as a cofactor for many enzymes and is important in several physiological …

Gut microbiota as a potential player in Mn-induced neurotoxicity

AA Tinkov, AC Martins, DS Avila, VA Gritsenko… - Biomolecules, 2021 - mdpi.com
Manganese (Mn) is an essential metal, which at high exposures causes neurotoxic effects
and neurodegeneration. The neurotoxic effects of Mn are mediated by neuroinflammation …

Impact of environmental risk factors on mitochondrial dysfunction, neuroinflammation, protein misfolding, and oxidative stress in the etiopathogenesis of parkinson's …

M Huang, A Bargues-Carot, Z Riaz, H Wickham… - International journal of …, 2022 - mdpi.com
As a prevalent progressive neurodegenerative disorder, Parkinson's disease (PD) is
characterized by the neuropathological hallmark of the loss of nigrostriatal dopaminergic …

Experimental models of chemically induced Parkinson's disease in zebrafish at the embryonic larval stage: a systematic review

P Briñez-Gallego, DG da Costa Silva… - Journal of Toxicology …, 2023 - Taylor & Francis
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of
dopaminergic neurons in the substantia nigra that results in a decrease in dopamine levels …