Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm
in diameter, including microorganisms, foreign substances, and apoptotic cells …

Integrins are the major family of adhesion molecules that mediate cell adhesion to the
extracellular matrix. They are essential for embryonic development and influence numerous …

One hundred years have passed since the death of Élie Metchnikoff (1845–1916). He was
the first to observe the uptake of particles by cells and realized the importance of this …

Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the
extracellular matrix. In this Review, we draw on experiments performed in mammalian cells …

Integrin αIIbβ3 is a highly abundant heterodimeric platelet receptor that can transmit
information bidirectionally across the plasma membrane, and plays a critical role in …

The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase with key roles in the
regulation of cell adhesion migration, proliferation and survival. In cancer FAK is a major …

The ability of animal cells to sense, adhere to and remodel their local extracellular matrix
(ECM) is central to control of cell shape, mechanical responsiveness, motility and signalling …

The disassembly of integrin-containing focal adhesions (FAs) at mitotic entry is essential for
cell rounding, mitotic retraction fibre formation, bipolar spindle positioning and chromosome …

The lymphocyte function-associated antigen-1 (LFA-1)(also known as CD11a/CD18 and
αLβ2), is just one of many integrins in the human body, but its significance is derived from its …