A cornerstone of the global initiative to eradicate polio is the widespread use of live and
inactivated poliovirus vaccines in extensive public health campaigns designed to prevent …

Globally, polio cases have reached an all-time low, and type 2 poliovirus (one of three) is
eradicated. Oral polio vaccine (OPV) has been the primary tool, however, in rare cases, OPV …

Background Use of oral live-attenuated polio vaccines (OPV), and injected inactivated polio
vaccines (IPV) has almost achieved global eradication of wild polio viruses. To address the …

Background Continued emergence and spread of circulating vaccine-derived type 2
polioviruses and vaccine-associated paralytic poliomyelitis from Sabin oral poliovirus …

Background Replacement of the trivalent oral poliovirus vaccine (tOPV) with bivalent types 1
and 3 oral poliovirus vaccine (bOPV) and global introduction of inactivated poliovirus …

To assess the dynamics of genetic reversion of live poliovirus vaccine in humans, we
studied molecular evolution in Sabin-like poliovirus isolates from Nigerian acute flaccid …

Background Following the global eradication of wild poliovirus, countries using live
attenuated oral poliovirus vaccines will transition to exclusive use of inactivated poliovirus …

Background Sabin inactivated and bivalent oral poliovirus vaccine (sIPV, bOPV) were
commonly used in China since 2016. We conducted an open-label, randomised, controlled …

Background Identification of mechanisms that limit poliovirus replication is crucial for
informing decisions aimed at global polio eradication. Studies of mucosal immunity induced …

Before the development of the inactivated poliovirus vaccine (IPV) and live oral poliovirus
vaccine (OPV), sporadic outbreaks of poliomyelitis were reported to cause as many as 18 …