Animal models of schizophrenia
CA Jones, DJG Watson… - British journal of …, 2011 - Wiley Online Library
Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …
The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice
JF Cryan, C Mombereau, A Vassout - Neuroscience & Biobehavioral …, 2005 - Elsevier
Since its introduction almost 20 years ago, the tail suspension test has become one of the
most widely used models for assessing antidepressant-like activity in mice. The test is based …
most widely used models for assessing antidepressant-like activity in mice. The test is based …
Drug craving and addiction: integrating psychological and neuropsychopharmacological approaches
IHA Franken - Progress in Neuro-Psychopharmacology and …, 2003 - Elsevier
In the present review, an integrated approach to craving and addiction is discussed, which is
based on recent insights from psychology and neuropsychopharmacology. An integrated …
based on recent insights from psychology and neuropsychopharmacology. An integrated …
Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic …
L Zuckerman, M Rehavi, R Nachman… - …, 2003 - nature.com
Prenatal exposure to infection is associated with increased liability to schizophrenia, and it is
believed that such an association is mediated by the maternal immune response, in …
believed that such an association is mediated by the maternal immune response, in …
Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia
Epidemiological studies have indicated an association between maternal bacterial and viral
infections during pregnancy and the higher incidence of schizophrenia in the resultant …
infections during pregnancy and the higher incidence of schizophrenia in the resultant …
Epidemiology-driven neurodevelopmental animal models of schizophrenia
Human epidemiological studies have provided compelling evidence that the risk of
developing schizophrenia is significantly enhanced following prenatal and/or perinatal …
developing schizophrenia is significantly enhanced following prenatal and/or perinatal …
To poly (I: C) or not to poly (I: C): advancing preclinical schizophrenia research through the use of prenatal immune activation models
The neurodevelopmental hypothesis of schizophrenia has been highly influential in shaping
our current thinking about modeling the disease in animals. Based on the findings provided …
our current thinking about modeling the disease in animals. Based on the findings provided …
In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders
Based on the epidemiological association between maternal infection during pregnancy and
enhanced risk of neurodevelopmental brain disorders in the offspring, a number of in-vivo …
enhanced risk of neurodevelopmental brain disorders in the offspring, a number of in-vivo …
Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain
Glycine transporters are endogenous regulators of the dual functions of glycine, which acts
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …
The prediction-error hypothesis of schizophrenia: new data point to circuit-specific changes in dopamine activity
Schizophrenia is a severe psychiatric disorder affecting 21 million people worldwide. People
with schizophrenia suffer from symptoms including psychosis and delusions, apathy …
with schizophrenia suffer from symptoms including psychosis and delusions, apathy …