Animal models of schizophrenia

CA Jones, DJG Watson… - British journal of …, 2011 - Wiley Online Library
Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …

The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice

JF Cryan, C Mombereau, A Vassout - Neuroscience & Biobehavioral …, 2005 - Elsevier
Since its introduction almost 20 years ago, the tail suspension test has become one of the
most widely used models for assessing antidepressant-like activity in mice. The test is based …

Drug craving and addiction: integrating psychological and neuropsychopharmacological approaches

IHA Franken - Progress in Neuro-Psychopharmacology and …, 2003 - Elsevier
In the present review, an integrated approach to craving and addiction is discussed, which is
based on recent insights from psychology and neuropsychopharmacology. An integrated …

Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic …

L Zuckerman, M Rehavi, R Nachman… - …, 2003 - nature.com
Prenatal exposure to infection is associated with increased liability to schizophrenia, and it is
believed that such an association is mediated by the maternal immune response, in …

Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia

U Meyer, J Feldon, M Schedlowski, BK Yee - … & Biobehavioral Reviews, 2005 - Elsevier
Epidemiological studies have indicated an association between maternal bacterial and viral
infections during pregnancy and the higher incidence of schizophrenia in the resultant …

Epidemiology-driven neurodevelopmental animal models of schizophrenia

U Meyer, J Feldon - Progress in neurobiology, 2010 - Elsevier
Human epidemiological studies have provided compelling evidence that the risk of
developing schizophrenia is significantly enhanced following prenatal and/or perinatal …

To poly (I: C) or not to poly (I: C): advancing preclinical schizophrenia research through the use of prenatal immune activation models

U Meyer, J Feldon - Neuropharmacology, 2012 - Elsevier
The neurodevelopmental hypothesis of schizophrenia has been highly influential in shaping
our current thinking about modeling the disease in animals. Based on the findings provided …

In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders

U Meyer, J Feldon, SH Fatemi - Neuroscience & Biobehavioral Reviews, 2009 - Elsevier
Based on the epidemiological association between maternal infection during pregnancy and
enhanced risk of neurodevelopmental brain disorders in the offspring, a number of in-vivo …

Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain

RJ Harvey, BK Yee - Nature reviews Drug discovery, 2013 - nature.com
Glycine transporters are endogenous regulators of the dual functions of glycine, which acts
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …

The prediction-error hypothesis of schizophrenia: new data point to circuit-specific changes in dopamine activity

SJ Millard, CE Bearden, KH Karlsgodt… - …, 2022 - nature.com
Schizophrenia is a severe psychiatric disorder affecting 21 million people worldwide. People
with schizophrenia suffer from symptoms including psychosis and delusions, apathy …