Chirality of new drug approvals (2013–2022): trends and perspectives
RU McVicker, NM O'Boyle - Journal of Medicinal Chemistry, 2024 - ACS Publications
Many drugs are chiral with their chirality determining their biological interactions, safety, and
efficacy. Since the 1980s, there has been a regulatory preference to bring single enantiomer …
efficacy. Since the 1980s, there has been a regulatory preference to bring single enantiomer …
Lipase Enzymes for Sustainable Synthesis of Pharmaceuticals and Chiral Organic Building Blocks
M Khanra, V Ravichandiran… - Advanced Sustainable …, 2023 - Wiley Online Library
Biocatalysis is a green and sustainable process for synthesizing chiral organic building
blocks and active pharmaceutical ingredients (API). United Nations' Sustainable …
blocks and active pharmaceutical ingredients (API). United Nations' Sustainable …
Streamlined Chemo-Enzymatic Synthesis of Molnupiravir via Lipase Catalyst
K Rosangzuala, RR Patlolla, A Shaikh, KAP Naik… - ACS …, 2024 - ACS Publications
An enzymatic approach for the synthesis of Molnupiravir has been developed using
immobilized lipase as a biocatalyst. This method involves a concise process of the …
immobilized lipase as a biocatalyst. This method involves a concise process of the …
Enzymatic kinetic resolution of an intermediate alcohol of the drug Tegoprazan using lipase from Thermomyces lanuginosus
D Pulivarthi, RR Patlolla, J Kuni, R Gajjala… - Biocatalysis and …, 2024 - Taylor & Francis
An enzymatic approach for the synthesis of intermediate alcohol of the drug tegoprazan in
99% ee at 20° C in hexane has been developed utilizing commercially available …
99% ee at 20° C in hexane has been developed utilizing commercially available …
Enzymatic approach to the synthesis of chiral intermediate of Rodatristat ethyl
D Pulivarthi, R Goparaju, RR Patlolla… - Biocatalysis and …, 2024 - Taylor & Francis
Ketoreductases are widely explored for the reduction of prochiral ketones for the preparation
of chiral alcohols. Though, the chiral Ir (III) catalyst has been used for the asymmetric …
of chiral alcohols. Though, the chiral Ir (III) catalyst has been used for the asymmetric …
Lipase enzymes for sustainable synthesis of chiral active pharmaceutical ingredients (API) and key starting materials
SP Swain, M Khanra - 2024 - chemrxiv.org
Biocatalysis is considered as a green and sustainable process for synthesis of chiral organic
building blocks and active pharmaceutical ingredients (API). Lipase catalysed kinetic and …
building blocks and active pharmaceutical ingredients (API). Lipase catalysed kinetic and …