The orphan G-protein-coupled receptor 35 (GPR35), although poorly characterised, is
attracting considerable interest as a therapeutic target. Marked differences in pharmacology …

Neutrophil recruitment from circulation to sites of inflammation is guided by multiple
chemoattractant cues emanating from tissue cells, immune cells, and platelets. Here, we …

Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …

GPR35 is a G protein-coupled receptor with notable involvement in modulating inflammatory
responses. Although the precise role of GPR35 in inflammation is not yet fully understood …

Background and purpose: GPR35, a member of the orphan G-protein-coupled receptor, was
recently implicated in colorectal cancer (CRC). However, whether targeting GPR35 by …

GPR35, an orphan receptor, has been waiting for its ligand since its cloning in 1998. Many
endogenous and exogenous molecules have been suggested to act as agonists of GPR35 …

Focusing on an important biomedical implication of allostery–design of allosteric drugs, we
describe characteristics of allosteric sites, effectors, and their modes of actions …

Cancer-specific alternatively spliced events (ASE) play a role in cancer pathogenesis and
can be targeted by immunotherapy, oligonucleotide therapy, and small molecule inhibition …

G protein-coupled receptors show preference for G protein subtypes but can recruit multiple
G proteins with various downstream signaling cascades. This functional selection can guide …

Dualsteric G protein-coupled receptor (GPCR) ligands are a class of bitopic ligands that
consist of an orthosteric pharmacophore, which binds to the pocket occupied by the …