[HTML][HTML] MYC on the path to cancer
CV Dang - Cell, 2012 - cell.com
The MYC oncogene contributes to the genesis of many human cancers. Recent insights into
its expression and function have led to therapeutic opportunities. MYC's activation by …
its expression and function have led to therapeutic opportunities. MYC's activation by …
Emerging roles of C-Myc in cancer stem cell-related signaling and resistance to cancer chemotherapy: a potential therapeutic target against colorectal cancer
M Elbadawy, T Usui, H Yamawaki, K Sasaki - International journal of …, 2019 - mdpi.com
Myc is a nuclear transcription factor that mainly regulates cell growth, cell cycle, metabolism,
and survival. Myc family proteins contain c-Myc, n-Myc, and l-Myc. Among them, c-Myc can …
and survival. Myc family proteins contain c-Myc, n-Myc, and l-Myc. Among them, c-Myc can …
Small-molecule MYC inhibitors suppress tumor growth and enhance immunotherapy
Small molecules that directly target MYC and are also well tolerated in vivo will provide
invaluable chemical probes and potential anti-cancer therapeutic agents. We developed a …
invaluable chemical probes and potential anti-cancer therapeutic agents. We developed a …
Strategies to inhibit Myc and their clinical applicability
JR Whitfield, ME Beaulieu, L Soucek - Frontiers in cell and …, 2017 - frontiersin.org
Myc is an oncogene deregulated in most—perhaps all—human cancers. Each Myc family
member, c-, L-, and N-Myc, has been connected to tumor progression and maintenance …
member, c-, L-, and N-Myc, has been connected to tumor progression and maintenance …
Therapeutic inhibition of Myc in cancer. Structural bases and computer-aided drug discovery approaches
LA Carabet, PS Rennie, A Cherkasov - International journal of molecular …, 2018 - mdpi.com
Myc (avian myelocytomatosis viral oncogene homolog) represents one of the most sought
after drug targets in cancer. Myc transcription factor is an essential regulator of cell growth …
after drug targets in cancer. Myc transcription factor is an essential regulator of cell growth …
Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases
Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …
Therapeutic strategies to inhibit MYC
MR McKeown, JE Bradner - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
MYC is a master regulator of stem cell state, embryogenesis, tissue homeostasis, and aging.
As in health, in disease MYC figures prominently. Decades of biological research have …
As in health, in disease MYC figures prominently. Decades of biological research have …
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease
Disordered proteins are challenging therapeutic targets, and no drug is currently in clinical
use that modifies the properties of their monomeric states. Here, we identify a small …
use that modifies the properties of their monomeric states. Here, we identify a small …
Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc
Abstract c-Myc is a transcription factor that is constitutively and aberrantly expressed in over
70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression …
70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression …
The MYCN protein in health and disease
MV Ruiz-Pérez, AB Henley, M Arsenian-Henriksson - Genes, 2017 - mdpi.com
MYCN is a member of the MYC family of proto-oncogenes. It encodes a transcription factor,
MYCN, involved in the control of fundamental processes during embryonal development …
MYCN, involved in the control of fundamental processes during embryonal development …