Cardiac in silico clinical trials can virtually assess the safety and efficacy of therapies using
human-based modelling and simulation. These technologies can provide mechanistic …

Computational models of the heart are increasingly being used in the development of
devices, patient diagnosis and therapy guidance. While software techniques have been …

Candida auris has globally emerged as a multidrug-resistant fungus linked to healthcare-
associated outbreaks. There is still limited evidence on its virulence, pathogenicity …

Abstract Cardiac Purkinje cells (PCs) are implicated in lethal arrhythmias caused by cardiac
diseases, mutations, and drug action. However, the pro-arrhythmic mechanisms in PCs are …

Newborn mammals, including piglets, exhibit natural heart regeneration after myocardial
infarction (MI) on postnatal day 1 (P1), but this ability is lost by postnatal day 7 (P7). The …

心肌细胞是一种高度分化的终末细胞, 自我更新能力差, 因而心梗发生后, 坏死的心肌细胞不能
得到有效的补充, 梗死区域很快被纤维组织所取代, 严重影响心功能. 近年研究发现 …

Depolarization sequences triggering mechanical contraction of the heart are largely
determined by the cardiac conduction system (CS). Many biophysical models of cardiac …

Cardiac malady due to Purkinje cardiomyofiber sarcocytosis in a goat as reported as
reported is reviewed. A two year old adult goat carcass was presented for postmortem …

Acute ischemic cardiac injury predisposes one to cognitive impairment, dementia, and
depression. Pathophysiologically, recent positron emission tomography data suggest …

Ventricular arrhythmias are a major cause of sudden cardiac death, which accounts for
about 50% of cardiovascular mortality worldwide. Understanding the mechanisms …