Structural and functional complexity of HSP90 in cellular homeostasis and disease
Abstract Heat shock protein 90 (HSP90) is a chaperone with vital roles in regulating
proteostasis, long recognized for its function in protein folding and maturation. A view is …
proteostasis, long recognized for its function in protein folding and maturation. A view is …
Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities
The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …
Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
Abstract Systems-level assessments of protein-protein interaction (PPI) network dysfunctions
are currently out-of-reach because approaches enabling proteome-wide identification …
are currently out-of-reach because approaches enabling proteome-wide identification …
Targeting stressor-induced dysfunctions in protein–protein interaction networks via epichaperomes
Diseases are manifestations of complex changes in protein–protein interaction (PPI)
networks whereby stressors, genetic, environmental, and combinations thereof, alter …
networks whereby stressors, genetic, environmental, and combinations thereof, alter …
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
A Bolaender, D Zatorska, H He, S Joshi… - Nature …, 2021 - nature.com
Diseases are a manifestation of how thousands of proteins interact. In several diseases,
such as cancer and Alzheimer's disease, proteome-wide disturbances in protein-protein …
such as cancer and Alzheimer's disease, proteome-wide disturbances in protein-protein …
Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)
Abstract Heat shock protein 90 (Hsp90) and its co-chaperones promote cancer, and
targeting Hsp90 holds promise for cancer treatment. Most of the efforts to harness this …
targeting Hsp90 holds promise for cancer treatment. Most of the efforts to harness this …
Cancer stem cells: biology and therapeutic implications
H Mayani, A Chávez-González… - Archives of Medical …, 2022 - Elsevier
It is well recognized that most cancers derive and progress from transformation and clonal
expansion of a single cell that possesses stem cell properties, ie, self-renewal and …
expansion of a single cell that possesses stem cell properties, ie, self-renewal and …
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells
Tissue homeostasis is maintained after stress by engaging and activating the hematopoietic
stem and progenitor compartments in the blood. Hematopoietic stem cells (HSCs) are …
stem and progenitor compartments in the blood. Hematopoietic stem cells (HSCs) are …
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
Cancer cell plasticity due to the dynamic architecture of interactome networks provides a
vexing outlet for therapy evasion. Here, through chemical biology approaches for systems …
vexing outlet for therapy evasion. Here, through chemical biology approaches for systems …
The penalty of stress‐Epichaperomes negatively reshaping the brain in neurodegenerative disorders
Adaptation to acute and chronic stress and/or persistent stressors is a subject of wide
interest in central nervous system disorders. In this context, stress is an effector of change in …
interest in central nervous system disorders. In this context, stress is an effector of change in …