Migraine is a common, disabling, and undertreated episodic brain disorder that is more
common in women than in men. Unbiased genome-wide association studies have identified …

Migraine—an episodic headache—affects more than 10% of the general population.
Despite recent progress, drug therapy for preventing and treating migraine remains …

This consistent and well-illustrated text is an up-to-date survey of cellular and molecular
events contributing to the assembly of the vertebrate nervous system. Chapters include a …

The zebrafish is a leading model for studies of vertebrate development and genetics. Its
embryonic motor behaviors are easy to assess (eg for mutagenic screens), the embryos …

Abstract Episodic ataxia type-2 (EA2) is caused by mutations in P/Q-type voltage-gated
calcium channels that are expressed at high densities in cerebellar Purkinje cells. Because …

The Ca2+ channel α1A-subunit is a voltage-gated, pore-forming membrane protein
positioned at the intersection of two important lines of research: one exploring the diversity of …

Insight into the molecular mechanisms involved in primary headaches is important to identify
drug targets for improving treatment of patients, but essentially lacking. Genetic research is …

Background The genetic basis of most common forms of human paroxysmal disorders of the
central nervous system, such as epilepsy, remains unidentified. Several animal models of …

The mouse mutant ducky, a model for absence epilepsy, is characterized by spike-wave
seizures and ataxia. The ducky gene was mapped previously to distal mouse chromosome …

Dystonia is a neurological disorder characterized by excessive involuntary muscle
contractions that lead to twisting movements or abnormal posturing. Traditional views place …