Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop
ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other …

Fast chemical communication in the nervous system is mediated by neurotransmitter-gated
ion channels. The prototypical member of this class of cell surface receptors is the cation …

Several neonicotinoids have recently been shown to activate the nicotinic acetylcholine
receptor (nAChR) on human neurons. Moreover, imidacloprid (IMI) and other members of …

Nicotinic acetylcholine receptors (nAChRs) are actively being investigated as therapeutic
targets for the treatment of pain and inflammation, but despite more than 30 years of …

Here we begin by briefly reviewing landmark structural studies on the nicotinic acetylcholine
receptor. We highlight challenges that had to be overcome to push through resolution …

Neonicotinoid pesticides, originally developed to target the insect nervous system, have
been reported to interact with human receptors and to activate rodent neurons. Therefore …

In the 1920s, tobacco companies created a marketing campaign for what would one day be
their most profitable series of products: mentholated tobacco cigarettes. Menthol provides …

Nicotinic acetylcholine receptors (nAChRs) are receptors for the neurotransmitter
acetylcholine and are members of the 'Cys-loop'family of pentameric ligand-gated ion …

Animals that wield toxins face self-intoxication. Poison frogs have a diverse arsenal of
defensive alkaloids that target the nervous system. Among them is epibatidine, a nicotinic …