DNA damage signalling and repair inhibitors: the long-sought-after Achilles' heel of cancer
D Velic, AM Couturier, MT Ferreira, A Rodrigue… - Biomolecules, 2015 - mdpi.com
For decades, radiotherapy and chemotherapy were the two only approaches exploiting DNA
repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major …
repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major …
[HTML][HTML] DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions
M Medová, M Medo, L Hovhannisyan… - Pharmacology & …, 2020 - Elsevier
The DNA-PK holoenzyme is a fundamental element of the DNA damage response
machinery (DDR), which is responsible for cellular genomic stability. Consequently, and …
machinery (DDR), which is responsible for cellular genomic stability. Consequently, and …
DNA–dependent protein kinase in telomere maintenance and protection
J Sui, S Zhang, BPC Chen - Cellular & Molecular Biology Letters, 2020 - Springer
This review focuses on DNA–dependent protein kinase (DNA–PK), which is the key
regulator of canonical non–homologous end–joining (NHEJ), the predominant mechanism …
regulator of canonical non–homologous end–joining (NHEJ), the predominant mechanism …
[HTML][HTML] Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis
G Shim, M Ricoul, WM Hempel, EI Azzam… - … Research/Reviews in …, 2014 - Elsevier
It is well established that ionizing radiation induces chromosomal damage, both following
direct radiation exposure and via non-targeted (bystander) effects, activating DNA damage …
direct radiation exposure and via non-targeted (bystander) effects, activating DNA damage …
[HTML][HTML] Artemis and its role in cancer
Artemis is a key nuclease involved in the non-homologous end joining repair pathway upon
DNA double-stranded breaks and during V (D) J recombination. It participates in various …
DNA double-stranded breaks and during V (D) J recombination. It participates in various …
APRIN (PDS5B) et PALB2, deux protéines impliquées dans la réparation de l'ADN par recombinaison homologue et l'apparition de cancers
A Couturier - 2016 - library-archives.canada.ca
Au Canada, en 2015, il était estimé que 78 000 personnes allaient mourir d'un cancer,
représentant 30% de tous les décès et faisant de celui-ci la première cause de mortalité. De …
représentant 30% de tous les décès et faisant de celui-ci la première cause de mortalité. De …
Investigation of Telomere maintenance in BRCA2 defective mammalian cell lines
Y Gozaly Chianea - 2014 - bura.brunel.ac.uk
BRCA2 is a highly penetrant breast cancer predisposing gene. The protein product of the
BRCA2 gene mediates repair of breaks in DNA, through Homologous Recombination (HR) …
BRCA2 gene mediates repair of breaks in DNA, through Homologous Recombination (HR) …